SCHEMBL6947428

SCHEMBL6947428

CC(C)OCCNS(=O)(=O)c1ccc2c(c1)C(Cl)(Cl)C(=O)N2

nearest known ligand 0.52

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
PKLR P30613 1/20 0.52
ALDH1A1 P00352 6/20 0.46
TSHR P16473 3/20 0.46
HTT P42858 1/20 0.44
POLB P06746 3/20 0.42
KMT2A Q03164 2/20 0.42
MEN1 O00255 1/20 0.42
PKM P14618 1/20 0.42
TP53 P04637 1/20 0.41
IDO1 P14902 2/20 0.41
MAPT P10636 2/20 0.41
SMN1; SMN2 Q16637 2/20 0.40
GAA P10253 2/20 0.39
KDM4E B2RXH2 1/20 0.38
NPC1 O15118 1/20 0.38
LMNA P02545 1/20 0.38
HPGD P15428 1/20 0.38
RAB9A P51151 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6943633 0.86 ALDH1A1 (0.58) PKLRALDH1A1TSHRHTTPOLB
SCHEMBL3915657 0.74 GAA (0.58) ALDH1A1TSHRHTTMAPTSMN1; SMN2
SCHEMBL6951212 0.73 PKLR (0.51) PKLRALDH1A1TSHRHTTKMT2A
SCHEMBL6946099 0.73 TBXAS1 (0.49) PKLRPOLBIDO1GAAKDM4E
SCHEMBL6951305 0.73 MGAT2 (0.60) PKLRALDH1A1POLBPKMTP53
SCHEMBL6949092 0.73 HTR2C (0.54) PKLRALDH1A1KMT2AMEN1TP53
SCHEMBL6948216 0.70 ALDH1A1 (0.58) PKLRALDH1A1POLBKMT2AIDO1
SCHEMBL1892301 0.70 ALDH1A1 (0.49) ALDH1A1TSHRHTTPOLBKMT2A
SCHEMBL6954051 0.70 PKLR (0.55) PKLRALDH1A1POLBKMT2AMEN1
SCHEMBL6950845 0.69 ALDH1A1 (0.57) PKLRALDH1A1TSHRHTTPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0988035-B1 CASPASES AND APOPTOSIS SMITHKLINE BEECHAM CORP (US) 2003-05-02 EP claimed
US-6214858-B1 PREVENTING AND TREATING EXCESSIVE CELL DEATH USING OXINDOLE DERIVATIVES SMITHKLINE BEECHAM CORPORATION 2001-04-10 US claimed
EP-0988035-B1 CASPASES AND APOPTOSIS SMITHKLINE BEECHAM CORP (US) 2003-05-02 EP disclosed
US-6214858-B1 PREVENTING AND TREATING EXCESSIVE CELL DEATH USING OXINDOLE DERIVATIVES SMITHKLINE BEECHAM CORPORATION 2001-04-10 US disclosed