Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.54 |
| ▸ | DPP4 | P27487 | 1/20 | 0.49 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.43 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.41 |
| ▸ | PRKCI | P41743 | 1/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.39 |
| ▸ | STAT3 | P40763 | 1/20 | 0.39 |
| ▸ | STAT1 | P42224 | 1/20 | 0.39 |
| ▸ | F2 | P00734 | 1/20 | 0.38 |
| ▸ | TPH1 | P17752 | 2/20 | 0.38 |
| ▸ | DHODH | Q02127 | 1/20 | 0.38 |
| ▸ | CFTR | P13569 | 1/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | RORC | P51449 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7228763 | 0.86 | DPP4 (0.44) | PDE10ADPP4ADORA3ABCG2STAT3 | |
| SCHEMBL7228648 | 0.82 | KCNH2 (0.42) | PDE10ADPP4ADORA3ABCG2STAT3 | |
| SCHEMBL27467049 | 0.79 | ADORA3 (0.45) | DPP4ADORA3ABCG2STAT3STAT1 | |
| SCHEMBL7229917 | 0.76 | ADORA3 (0.58) | ADORA3KDM4EALDH1A1 | |
| SCHEMBL7229190 | 0.74 | PDE10A (0.42) | PDE10APRKCIDHODHKDM4EALDH1A1 | |
| SCHEMBL7228141 | 0.69 | TRPV3 (0.46) | ADORA3ALDH1A1 | |
| SCHEMBL29712526 | 0.68 | KIF11 (0.71) | DPP4ABCG2ALDH1A1 | |
| SCHEMBL28465080 | 0.68 | KIF11 (0.71) | DPP4ABCG2ALDH1A1 | |
| SCHEMBL2468818 | 0.66 | PLAU (0.49) | DPP4PTGDR2STAT3STAT1DHODH | |
| SCHEMBL3367635 | 0.66 | DPP4 (1.00) | DPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6620817-B1 | Antiinflammatory, antiarthritic agents; autoimmune and rheumatic diseases | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 2003-09-16 | — | — | US | claimed |
| EP-1236721-A1 | 5-CHLORO-6-PHENYL-2-(4-TRIFLUOROMETHYLPHENYL)-4-PYRIMIDINYLAMINO]ACETAMIDE DERIVATIVES, PROCESS FOR PRODUCING THE SAME, MEDICINAL COMPOSITIONS CONTAINING THE SAME AND INTERMEDIATE OF THESE COMPOUNDS | Dainippon Pharmaceutical Co., Ltd. (JP) | 2002-09-04 | — | — | EP | claimed |
| CN-1170823-C | [ 5-chloro-6-phenyl-2- (4-trifluoromethylphenyl) -4-pyrimidinylamino ] acetamide derivatives, process for preparing the same, pharmaceutical compositions containing the same and intermediates for preparing the same | 大日本制药株式会社 | 2004-10-13 | — | — | CN | disclosed |
| CN-1170823-C | [ 5-chloro-6-phenyl-2- (4-trifluoromethylphenyl) -4-pyrimidinylamino ] acetamide derivatives, process for preparing the same, pharmaceutical compositions containing the same and intermediates for preparing the same | 大日本制药株式会社 | 2004-10-13 | — | — | CN | disclosed |
| US-6620817-B1 | Antiinflammatory, antiarthritic agents; autoimmune and rheumatic diseases | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 2003-09-16 | — | — | US | disclosed |
| US-6620817-B1 | Antiinflammatory, antiarthritic agents; autoimmune and rheumatic diseases | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 2003-09-16 | — | — | US | disclosed |
| US-6620817-B1 | Antiinflammatory, antiarthritic agents; autoimmune and rheumatic diseases | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 2003-09-16 | — | — | US | disclosed |
| EP-1236721-A4 | 5-CHLORO-6-PHENYL-2-(4-TRIFLUOROMETHYLPHENYL)-4-PYRIMIDINYLAMINO]ACETAMIDE DERIVATIVES, PROCESS FOR PRODUCING THE SAME, MEDICINAL COMPOSITIONS CONTAINING THE SAME AND INTERMEDIATE OF THESE COMPOUNDS | DAINIPPON PHARMACEUTICAL CO (JP) | 2003-02-05 | — | — | EP | disclosed |
| CN-1390207-A | [ 5-chloro-6-phenyl-2- (4-trifluoromethylphenyl) -4-pyrimidinylamino ] acetamide derivatives, processes for preparing the same, pharmaceutical compositions containing the same and intermediates for these compounds | DAINIPPON PHARMACEUTICAL CO (JP) | 2003-01-08 | — | — | CN | disclosed |
| CN-1390207-A | [ 5-chloro-6-phenyl-2- (4-trifluoromethylphenyl) -4-pyrimidinylamino ] acetamide derivatives, processes for preparing the same, pharmaceutical compositions containing the same and intermediates for these compounds | DAINIPPON PHARMACEUTICAL CO (JP) | 2003-01-08 | — | — | CN | disclosed |
| EP-1236721-A1 | 5-CHLORO-6-PHENYL-2-(4-TRIFLUOROMETHYLPHENYL)-4-PYRIMIDINYLAMINO]ACETAMIDE DERIVATIVES, PROCESS FOR PRODUCING THE SAME, MEDICINAL COMPOSITIONS CONTAINING THE SAME AND INTERMEDIATE OF THESE COMPOUNDS | Dainippon Pharmaceutical Co., Ltd. (JP) | 2002-09-04 | — | — | EP | disclosed |
| EP-1236721-A1 | 5-CHLORO-6-PHENYL-2-(4-TRIFLUOROMETHYLPHENYL)-4-PYRIMIDINYLAMINO]ACETAMIDE DERIVATIVES, PROCESS FOR PRODUCING THE SAME, MEDICINAL COMPOSITIONS CONTAINING THE SAME AND INTERMEDIATE OF THESE COMPOUNDS | Dainippon Pharmaceutical Co., Ltd. (JP) | 2002-09-04 | — | — | EP | disclosed |
| WO-2001036392-A1 | [5-CHLORO-6-PHENYL-2-(4-TRIFLUOROMETHYLPHENYL)-4-PYRIMIDINYLAMINO]ACETAMIDE DERIVATIVES, PROCESS FOR PRODUCING THE SAME, MEDICINAL COMPOSITIONS CONTAINING THE SAME AND INTERMEDIATE OF THESE COMPOUNDS | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 2001-05-25 | — | — | WO | disclosed |
| WO-2001036392-A1 | [5-CHLORO-6-PHENYL-2-(4-TRIFLUOROMETHYLPHENYL)-4-PYRIMIDINYLAMINO]ACETAMIDE DERIVATIVES, PROCESS FOR PRODUCING THE SAME, MEDICINAL COMPOSITIONS CONTAINING THE SAME AND INTERMEDIATE OF THESE COMPOUNDS | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 2001-05-25 | — | — | WO | disclosed |