Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV3 | Q8NET8 | 13/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
| ▸ | FPR2 | P25090 | 1/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.43 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7229917 | 0.78 | ADORA3 (0.58) | ADORA3FPR2SCN9AALDH1A1 | |
| SCHEMBL3725622 | 0.75 | SCN9A (0.55) | TRPV3FPR2SCN9A | |
| SCHEMBL19956186 | 0.75 | SCN9A (0.78) | FPR2SCN9A | |
| SCHEMBL3429809 | 0.73 | FAAH (0.62) | TRPV3CYP2D6 | |
| SCHEMBL28931217 | 0.72 | L3MBTL1 (0.57) | ADORA3L3MBTL1ALDH1A1 | |
| SCHEMBL24279571 | 0.71 | KIF11 (0.54) | — | |
| SCHEMBL893266 | 0.71 | TRPV3 (0.47) | TRPV3SCN9A | |
| SCHEMBL8030882 | 0.70 | TRPV3 (0.51) | TRPV3 | |
| SCHEMBL3794168 | 0.70 | TRPV3 (0.48) | TRPV3SCN9A | |
| SCHEMBL27920440 | 0.69 | CCRL2 (0.51) | SCN9ANR3C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6620817-B1 | Antiinflammatory, antiarthritic agents; autoimmune and rheumatic diseases | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 2003-09-16 | — | — | US | disclosed |
| EP-1236721-A1 | 5-CHLORO-6-PHENYL-2-(4-TRIFLUOROMETHYLPHENYL)-4-PYRIMIDINYLAMINO]ACETAMIDE DERIVATIVES, PROCESS FOR PRODUCING THE SAME, MEDICINAL COMPOSITIONS CONTAINING THE SAME AND INTERMEDIATE OF THESE COMPOUNDS | Dainippon Pharmaceutical Co., Ltd. (JP) | 2002-09-04 | — | — | EP | disclosed |
| JP-2001139558-A | [2-(4-TRIFLUOROMETHYLPHENYL)-4- PYRIMIDINYLAMINO]ACETAMIDE DERIVATIVE | DAINIPPON PHARMACEUT CO LTD | 2001-05-22 | — | — | JP | disclosed |
| JP-2001139558-A | [2-(4-TRIFLUOROMETHYLPHENYL)-4- PYRIMIDINYLAMINO]ACETAMIDE DERIVATIVE | DAINIPPON PHARMACEUT CO LTD | 2001-05-22 | — | — | JP | disclosed |