Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | IKBKB | O14920 | 1/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.35 |
| ▸ | PTGFR | P43088 | 7/20 | 0.34 |
| ▸ | DHODH | Q02127 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | PRKCI | P41743 | 1/20 | 0.33 |
| ▸ | ADK | P55263 | 1/20 | 0.33 |
| ▸ | CDK1 | P06493 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6946847 | 0.74 | PDE10A (0.54) | PDE10AKDM4EALDH1A1GAADHODH | |
| SCHEMBL7230333 | 0.67 | SYK (0.35) | GAALMNASMN1; SMN2 | |
| SCHEMBL7077947 | 0.64 | DHODH (0.40) | KDM4EALDH1A1GAALMNADHODH | |
| SCHEMBL7237373 | 0.63 | POLB (0.34) | LMNASMN1; SMN2 | |
| SCHEMBL718683 | 0.63 | ALPL (0.34) | KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL5810835 | 0.61 | PDE4B (0.61) | PDE10AKDM4EALDH1A1GAALMNA | |
| SCHEMBL7502850 | 0.59 | MEN1 (0.59) | PDE10AKDM4EALDH1A1GAASMN1; SMN2 | |
| SCHEMBL30009492 | 0.58 | BCAT2 (0.49) | IKBKBDHODH | |
| SCHEMBL3253576 | 0.58 | PDE10A (0.55) | PDE10AKDM4EALDH1A1GAAIKBKB | |
| SCHEMBL4516645 | 0.58 | MEN1 (0.67) | PDE10AALDH1A1GAALMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6620817-B1 | Antiinflammatory, antiarthritic agents; autoimmune and rheumatic diseases | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 2003-09-16 | — | — | US | claimed |