Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | STS | P08842 | 2/20 | 0.35 |
| ▸ | RORC | P51449 | 1/20 | 0.35 |
| ▸ | OGA | O60502 | 1/20 | 0.35 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | LSS | P48449 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.33 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7232122 | 0.85 | PROKR1 (0.46) | PROKR1RORCP2RX3MAPTLMNA | |
| SCHEMBL7230684 | 0.82 | PROKR1 (0.43) | PROKR1RORCP2RX3MAPTLMNA | |
| SCHEMBL6952146 | 0.80 | MAPT (0.41) | NFKB1STSMAPTTSHRLMNA | |
| SCHEMBL7237312 | 0.79 | POLB (0.30) | L3MBTL1POLB | |
| SCHEMBL5497099 | 0.73 | MEN1 (0.55) | NFKB1NFKB2RELASTSLMNA | |
| SCHEMBL6787059 | 0.72 | MMP13 (0.42) | MAPTLMNATP53DRD2POLB | |
| SCHEMBL6954217 | 0.69 | GPR119 (0.36) | RORCL3MBTL1POLB | |
| SCHEMBL6347674 | 0.69 | ESR2 (0.38) | RORC | |
| SCHEMBL7238651 | 0.68 | MAPK1 (0.42) | TSHRLMNATP53L3MBTL1POLB | |
| SCHEMBL27552573 | 0.68 | PROKR1 (0.40) | PROKR1NFKB1NFKB2RELAOGA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6506764-B1 | B-X-(CH2)m-CR1R2-(CH2)n-CO-Y (I) have therapeutic utility as inhibitors of metalloproteinases etc. for medicine by human articular cartilage cells and also involved in the destruction of myelin basic protein, a phenomenon associated with | DARWIN DISCOVERY, LTD. (GB) | 2003-01-14 | — | — | US | disclosed |