Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKLR | P30613 | 1/20 | 0.42 |
| ▸ | CASP3 | P42574 | 2/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6950459 | 0.81 | KMT2A (0.48) | PKLRCASP3NAMPTALDH1A1GAA | |
| SCHEMBL7736087 | 0.80 | CASP3 (0.64) | CASP3NAMPTGAAMAOAMAOB | |
| SCHEMBL8307133 | 0.79 | CASP3 (0.63) | PKLRCASP3LMNAALDH1A1GAA | |
| SCHEMBL7804480 | 0.79 | CASP3 (0.49) | CASP3NAMPT | |
| SCHEMBL6946269 | 0.78 | PKLR (0.44) | PKLRCASP3LMNAALDH1A1GAA | |
| SCHEMBL2333739 | 0.74 | TDP1 (0.60) | NAMPTHTTLMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL8307129 | 0.73 | PKLR (0.50) | PKLRHTTLMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL8307006 | 0.72 | PKLR (0.42) | PKLRCASP3SMN1; SMN2ALDH1A1TDP1 | |
| SCHEMBL11174132 | 0.71 | TDP1 (0.51) | NAMPTHTTLMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL30555219 | 0.68 | PKLR (0.55) | PKLRALDH1A1TDP1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0988035-B1 | CASPASES AND APOPTOSIS | SMITHKLINE BEECHAM CORP (US) | 2003-05-02 | — | — | EP | claimed |
| US-6214858-B1 | PREVENTING AND TREATING EXCESSIVE CELL DEATH USING OXINDOLE DERIVATIVES | SMITHKLINE BEECHAM CORPORATION | 2001-04-10 | — | — | US | claimed |
| EP-0988035-B1 | CASPASES AND APOPTOSIS | SMITHKLINE BEECHAM CORP (US) | 2003-05-02 | — | — | EP | disclosed |
| US-6214858-B1 | PREVENTING AND TREATING EXCESSIVE CELL DEATH USING OXINDOLE DERIVATIVES | SMITHKLINE BEECHAM CORPORATION | 2001-04-10 | — | — | US | disclosed |