Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | CASP3 | P42574 | 4/20 | 0.47 |
| ▸ | PKLR | P30613 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | MAOA | P21397 | 3/20 | 0.40 |
| ▸ | MAOB | P27338 | 2/20 | 0.40 |
| ▸ | IKBKB | O14920 | 1/20 | 0.40 |
| ▸ | CHUK | O15111 | 1/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.40 |
| ▸ | AURKAIP1 | Q9NWT8 | 1/20 | 0.40 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | RAF1 | P04049 | 1/20 | 0.38 |
| ▸ | VCAM1 | P19320 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8307133 | 0.85 | CASP3 (0.63) | ALDH1A1CASP3PKLRGAAMAOA | |
| SCHEMBL6946269 | 0.84 | PKLR (0.44) | KMT2AALDH1A1KDM4ECASP3PKLR | |
| SCHEMBL6949029 | 0.81 | PKLR (0.42) | ALDH1A1CASP3PKLRGAAMAOA | |
| SCHEMBL8307006 | 0.80 | PKLR (0.42) | ALDH1A1KDM4ECASP3PKLRGAA | |
| SCHEMBL8307129 | 0.79 | PKLR (0.50) | ALDH1A1RXFP1KDM4EPKLRGAA | |
| SCHEMBL7566978 | 0.77 | CASP3 (0.74) | KMT2AALDH1A1RXFP1KDM4EMEN1 | |
| SCHEMBL6954051 | 0.73 | PKLR (0.55) | KMT2AALDH1A1KDM4EMEN1PKLR | |
| SCHEMBL26376297 | 0.70 | KMT2A (0.58) | KMT2AALDH1A1RXFP1KDM4EMEN1 | |
| SCHEMBL11576737 | 0.70 | CA12 (0.59) | KMT2AALDH1A1RXFP1KDM4EMEN1 | |
| SCHEMBL2414975 | 0.70 | SIGMAR1 (0.57) | KMT2AALDH1A1RXFP1KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0988035-B1 | CASPASES AND APOPTOSIS | SMITHKLINE BEECHAM CORP (US) | 2003-05-02 | — | — | EP | claimed |
| US-6214858-B1 | PREVENTING AND TREATING EXCESSIVE CELL DEATH USING OXINDOLE DERIVATIVES | SMITHKLINE BEECHAM CORPORATION | 2001-04-10 | — | — | US | claimed |
| EP-0988035-B1 | CASPASES AND APOPTOSIS | SMITHKLINE BEECHAM CORP (US) | 2003-05-02 | — | — | EP | disclosed |
| US-6214858-B1 | PREVENTING AND TREATING EXCESSIVE CELL DEATH USING OXINDOLE DERIVATIVES | SMITHKLINE BEECHAM CORPORATION | 2001-04-10 | — | — | US | disclosed |