Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.45 |
| ▸ | SCD | O00767 | 1/20 | 0.43 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.43 |
| ▸ | GRM5 | P41594 | 1/20 | 0.43 |
| ▸ | SPR | P35270 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CHKA | P35790 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.42 |
| ▸ | FAAH | O00519 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | PRKG1 | Q13976 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.41 |
| ▸ | NCF1 | P14598 | 1/20 | 0.41 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1856770 | 0.79 | LMNA (0.55) | LMNAKCNH2HRH3HSD11B1SCD | |
| SCHEMBL10194714 | 0.78 | QDPR (0.58) | LMNAKCNH2HSD11B1SCDSCD5 | |
| SCHEMBL6826798 | 0.78 | LMNA (0.53) | LMNAKCNH2HRH3HSD11B1SCD | |
| SCHEMBL6950631 | 0.75 | GPR119 (0.53) | LMNANAMPTKDM4E | |
| SCHEMBL7444560 | 0.75 | ADRB2 (0.66) | LMNACA2CHKAADRB2NCF1 | |
| SCHEMBL373584 | 0.74 | SLC18A3 (0.61) | HRH3ADRB2NCF1PLD1 | |
| SCHEMBL15317770 | 0.74 | LMNA (0.53) | LMNAHSD11B1SCDSCD5GRM5 | |
| SCHEMBL22300553 | 0.74 | LMNA (0.53) | LMNAHRH3HSD11B1SCDSCD5 | |
| SCHEMBL27282433 | 0.74 | NAMPT (0.60) | LMNAKCNH2HRH3HSD11B1SCD | |
| SCHEMBL27888979 | 0.73 | KCNH2 (0.73) | KCNH2HRH3HSD11B1SCD5SPR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0966462-B1 | HETEROCYCLIC COMPOUNDS USEFUL AS OXIDO-SQUALENE CYCLASE INHIBITORS | ASTRAZENECA AB (SE) | 2003-06-11 | — | — | EP | disclosed |
| US-6391880-B1 | ANTICHOLESTEROL AGENTS | ZENECA LIMITED (GB) | 2002-05-21 | — | — | US | disclosed |
| EP-0966462-A1 | HETEROCYCLIC COMPOUNDS USEFUL AS OXIDO-SQUALENE CYCLASE INHIBITORS | ZENECA LIMITED (GB) | 1999-12-29 | — | — | EP | disclosed |
| WO-1998035959-A1 | HETEROCYCLIC COMPOUNDS USEFUL AS OXIDO-SQUALENE CYCLASE INHIBITORS | ZENECA LIMITED (GB) | 1998-08-20 | — | — | WO | disclosed |