Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 1/20 | 0.49 |
| ▸ | NOS1 | P29475 | 1/20 | 0.49 |
| ▸ | NOS2 | P35228 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | METAP2 | P50579 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 8/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.36 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2624111 | 0.72 | HTR6 (0.42) | HTR6ALDH1A1NPSR1HTR2BKDM4E | |
| SCHEMBL1706536 | 0.69 | METAP2 (0.44) | KMT2AMETAP2HTR6NPSR1HTR2B | |
| SCHEMBL17702697 | 0.68 | NOS3 (0.52) | NOS3NOS1NOS2KMT2AMEN1 | |
| SCHEMBL1599381 | 0.68 | KMT2A (0.57) | NOS3NOS1NOS2KMT2AMEN1 | |
| (Phenylsulfonyl)Benzene SCHEMBL11784548 | 0.68 | HTR6 (0.64) | KMT2AMEN1HTR6ALDH1A1HPGD | |
| SCHEMBL15397397 | 0.67 | NOS3 (0.50) | NOS3NOS1NOS2KMT2AMEN1 | |
| SCHEMBL5422878 | 0.67 | CYP2A6 (0.48) | NOS3NOS1NOS2KMT2AMEN1 | |
| SCHEMBL394598 | 0.66 | NOS2 (1.00) | NOS3NOS1NOS2NPSR1TSHR | |
| SCHEMBL8533330 | 0.66 | NOS3 (0.59) | NOS3NOS1NOS2ALDH1A1MAPT | |
| SCHEMBL28212024 | 0.66 | KMT2A (0.58) | KMT2AMEN1RAB9AHTR6TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0931790-B1 | Method for producing 2-sulfonylpyridine derivates and method for producing 2-( (2-pyridyl)methyl)thio)-1H-benzimidazole derivates | KURARAY CO (JP) | 2003-05-14 | — | — | EP | disclosed |
| US-6350876-B2 | REACTING SULFONYL CYANIDE DERIVATIVE WITH ALPHA,BETA-UNSAT-URATED CARBONYL COMPOUND; ORGANOLITHIUM COMPOUND; STARTING MATERIAL/INTERMEDIATE FOR DRUG SYNTHESIS (ANTI-PARKINSON'S DRUG LAZABEMIDE) AND AGRICULTURAL CHEMICALS (PESTICIDES) | KURARAY CO., LTD. (JP) | 2002-02-26 | — | — | US | disclosed |
| US-20010051726-A1 | Method for producing 2-sulfonylpyridine derivatives and method for producing 2- { [ (2-pyridyl) methyl] thio} -1H-benzimidazole derivatives | KURARAY CO., LTD. (JP) | 2001-12-13 | — | — | US | disclosed |
| US-6197962-B1 | REACTING A,B-UNSATURATED CARBONYL COMPOUND WITH A SULFONYL CYANIDE; CYCLIZATION | KURARAY CO., LTD. (JP) | 2001-03-06 | — | — | US | disclosed |
| EP-0931790-A2 | Method for producing 2-sulfonylpyridine derivates and method for producing 2-( (2-pyridyl)methyl)thio)-1H-benzimidazole derivates | KURARAY CO., LTD. (JP) | 1999-07-28 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010051726-A1 | Method for producing 2-sulfonylpyridine derivatives and method for producing 2- { [ (2-pyridyl) methyl] thio} -1H-benzimidazole derivatives | PDXK, KCNJ2, KCNJ1 | NOS3 3068/4885NOS1 2913/4885NOS2 1957/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.