Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7209767 | 0.98 | EPHX2 (0.47) | EPHX2ALDH1A1HPGDGLALMNA | |
| SCHEMBL8655174 | 0.84 | GBA1 (0.47) | ALDH1A1HPGDGLALMNAMEN1 | |
| SCHEMBL7368098 | 0.84 | LMNA (0.49) | EPHX2ALDH1A1HPGDGLALMNA | |
| SCHEMBL9342644 | 0.76 | AKR1B1 (0.46) | EPHX2ALDH1A1HPGDLMNAUSP2 | |
| SCHEMBL800064 | 0.73 | EPHX2 (0.56) | EPHX2ALDH1A1HPGDGLALMNA | |
| SCHEMBL17801467 | 0.72 | LMNA (0.46) | EPHX2ALDH1A1HPGDGLALMNA | |
| SCHEMBL5408882 | 0.72 | CES2 (0.36) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL11504283 | 0.72 | EPHX2 (0.46) | EPHX2ALDH1A1HPGDGLALMNA | |
| SCHEMBL163232 | 0.72 | EPHX2 (0.59) | EPHX2ALDH1A1HPGDGLAMEN1 | |
| Ethylbenzene SCHEMBL27590828 | 0.70 | SMN1; SMN2 (0.53) | EPHX2ALDH1A1HPGDMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268433-A1 | CYCLIC LACTAMS AS INHIBITORS OF A-BETA-PROTEIN PRODUCTION | Bristol-Myers Squibb Pharma Company (US) | 2003-01-02 | — | — | EP | disclosed |
| WO-2001074783-A1 | CYCLIC LACTAMS AS INHIBITORS OF A ΒΕΤΑ PROTEIN PRODUCTION | DUPONT PHARMACEUTICALS COMPANY (US) | 2001-10-11 | — | — | WO | disclosed |