Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | PHGDH | O43175 | 1/20 | 0.36 |
| ▸ | MGLL | Q99685 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8487636 | 0.84 | L3MBTL1 (0.42) | TDP1 | |
| SCHEMBL21078258 | 0.82 | HTR1A (0.46) | HTR1ATDP1CYP1A2HSD17B10CHRM1 | |
| SCHEMBL8489074 | 0.82 | L3MBTL1 (0.44) | TDP1ALDH1A1 | |
| SCHEMBL21428423 | 0.81 | HSD17B10 (0.53) | HTR1ATDP1CYP1A2HSD17B10CHRM1 | |
| SCHEMBL16592139 | 0.80 | RBP4 (0.48) | HTR1ATDP1CYP1A2HSD17B10CHRM1 | |
| SCHEMBL22645244 | 0.80 | RBP4 (0.48) | HTR1ATDP1CYP1A2HSD17B10CHRM1 | |
| SCHEMBL20416320 | 0.79 | CYP2C19 (0.47) | HTR1ATDP1CYP1A2HSD17B10CHRM1 | |
| SCHEMBL8488986 | 0.79 | CYP3A4 (0.47) | ALDH1A1 | |
| SCHEMBL5482918 | 0.79 | CYP3A4 (0.47) | ALDH1A1 | |
| SCHEMBL6134531 | 0.79 | CA2 (0.39) | HSD11B1CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003103652-A1 | METHODS OF TREATING ALZHEIMER’S DISEASE USING AROMATICALLY SUBSTITUTED ω-AMINO-ALKANOIC ACID AMIDES AND ALKANOIC ACID DIAMIDES | ELAN PHARMACEUTICALS, INC. (US) | 2003-12-18 | — | — | WO | disclosed |