Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | NQO2 | P16083 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | THRB | P10828 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.36 |
| ▸ | TUBB | P07437 | 1/20 | 0.36 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.36 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.36 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.36 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6946183 | 0.88 | LTA4H (0.52) | LTA4HGAALMNAHPGDSMN1; SMN2 | |
| SCHEMBL6947814 | 0.82 | LMNA (0.53) | LTA4HGAALMNAHPGDSMN1; SMN2 | |
| SCHEMBL6943711 | 0.79 | LTA4H (0.43) | LTA4HLMNAHPGDSMN1; SMN2CALM1 | |
| SCHEMBL6949388 | 0.78 | LTA4H (0.42) | LTA4HGAALMNAHPGDSMN1; SMN2 | |
| SCHEMBL7077380 | 0.78 | LTA4H (0.42) | LTA4HLMNAHPGDSMN1; SMN2CALM1 | |
| SCHEMBL30079648 | 0.76 | CA2 (0.39) | GAAALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL27171654 | 0.76 | CA2 (0.39) | GAAALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL6949776 | 0.76 | ALDH1A1 (0.41) | LTA4HLMNAHPGDSMN1; SMN2ALDH1A1 | |
| SCHEMBL6946931 | 0.75 | LMNA (0.41) | LTA4HGAALMNAHPGDSMN1; SMN2 | |
| SCHEMBL6948033 | 0.75 | PTPN1 (0.47) | LMNAHPGDCALM1MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1082121-A4 | HIV INTEGRASE INHIBITORS | MERCK & CO INC (US) | 2003-02-05 | — | — | EP | disclosed |
| US-6380249-B1 | HIV integrase inhibitors | MERCK & CO., INC. | 2002-04-30 | — | — | US | disclosed |
| EP-1082121-A1 | HIV INTEGRASE INHIBITORS | Merck & Co., Inc. (US) | 2001-03-14 | — | — | EP | disclosed |
| WO-1999062520-A1 | HIV INTEGRASE INHIBITORS | MERCK & CO., INC. (US) | 1999-12-09 | — | — | WO | disclosed |