Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | PDE5A | O76074 | 1/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.35 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.35 |
| ▸ | CCR5 | P51681 | 4/20 | 0.35 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | TACR1 | P25103 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6956608 | 0.88 | TACR1 (0.41) | TACR1 | |
| SCHEMBL6956400 | 0.87 | SLC6A4 (0.39) | HTTPDE5AJAK2JAK3PTK2 | |
| SCHEMBL6947706 | 0.86 | MEN1 (0.38) | TACR1 | |
| SCHEMBL6950872 | 0.86 | HTT (0.45) | RIPK1HTTGPR119TACR1 | |
| SCHEMBL6959517 | 0.84 | ALDH1A1 (0.38) | HTTJAK2JAK3PTK2ALDH1A1 | |
| SCHEMBL7075359 | 0.83 | MEN1 (0.43) | — | |
| SCHEMBL6949144 | 0.81 | GPR119 (0.39) | HTTGPR119 | |
| SCHEMBL4602631 | 0.81 | MEN1 (0.39) | HTT | |
| SCHEMBL5562101 | 0.81 | MEN1 (0.39) | HTT | |
| SCHEMBL6952811 | 0.80 | PDE4B (0.50) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863875-B1 | NEW 4-(OXYALKOXYPHENYL)-3-OXY-PIPERIDINES FOR TREATING HEART AND KIDNEY INSUFFICIENCY | HOFFMANN LA ROCHE (CH) | 2003-06-04 | — | — | EP | disclosed |