Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.37 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | RBP4 | P02753 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.34 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.34 |
| ▸ | RHOA | P61586 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6960005 | 0.87 | MEN1 (0.39) | ALDH1A1KMT2AKDM4EKDM4DGAA | |
| SCHEMBL6952756 | 0.86 | HTT (0.42) | ALDH1A1KMT2AKDM4EGAAHTT | |
| SCHEMBL6956400 | 0.84 | SLC6A4 (0.39) | JAK2JAK3PTK2HTTUSP30 | |
| SCHEMBL6950896 | 0.84 | RIPK1 (0.45) | ALDH1A1JAK2JAK3PTK2HTT | |
| SCHEMBL6950872 | 0.84 | HTT (0.45) | KMT2AHTTSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL6956608 | 0.83 | TACR1 (0.41) | KMT2AKDM4E | |
| SCHEMBL7075359 | 0.80 | MEN1 (0.43) | KMT2ASLC6A4SLC6A3 | |
| SCHEMBL6952811 | 0.80 | PDE4B (0.50) | KMT2ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL7076959 | 0.80 | REN (0.48) | — | |
| SCHEMBL5562101 | 0.78 | MEN1 (0.39) | KMT2AHTTSLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863875-B1 | NEW 4-(OXYALKOXYPHENYL)-3-OXY-PIPERIDINES FOR TREATING HEART AND KIDNEY INSUFFICIENCY | HOFFMANN LA ROCHE (CH) | 2003-06-04 | — | — | EP | disclosed |