Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | PADI4 | Q9UM07 | 7/20 | 0.35 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | DHODH | Q02127 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.31 |
| ▸ | BCKDK | O14874 | 1/20 | 0.31 |
| ▸ | PMM2 | O15305 | 1/20 | 0.31 |
| ▸ | MPI | P34949 | 1/20 | 0.31 |
| ▸ | PHOSPHO1 | Q8TCT1 | 1/20 | 0.31 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.31 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6952132 | 1.00 | MAPT (0.36) | MAPTNPC1GAARAB9APADI4 | |
| SCHEMBL6960303 | 0.80 | SIRT2 (0.39) | TBXAS1PTGDR2SIRT2 | |
| SCHEMBL7672734 | 0.77 | PADI4 (0.35) | MAPTNPC1GAARAB9APADI4 | |
| SCHEMBL6714980 | 0.71 | RAB9A (0.42) | NPC1GAARAB9AKDM4ESMN1; SMN2 | |
| SCHEMBL6714982 | 0.71 | RAB9A (0.42) | NPC1GAARAB9AKDM4ESMN1; SMN2 | |
| SCHEMBL6963779 | 0.70 | SIRT2 (0.39) | SIRT2 | |
| SCHEMBL2893771 | 0.70 | GPR35 (0.58) | RAB9ATBXAS1PTGDR2DHODHBCKDK | |
| SCHEMBL7082564 | 0.69 | CYP1B1 (0.53) | MAPTKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL7082566 | 0.69 | CYP1B1 (0.53) | MAPTKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL6926964 | 0.68 | KDM4E (0.43) | MAPTKDM4EALDH1A1SMN1; SMN2SIRT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0974584-B1 | FUSED RING COMPOUNDS, PROCESS FOR PRODUCING THE SAME AND USE THEREOF | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-01-15 | — | — | EP | disclosed |
| EP-0974584-A1 | FUSED RING COMPOUNDS, PROCESS FOR PRODUCING THE SAME AND USE THEREOF | Takeda Chemical Industries, Ltd. (JP) | 2000-01-26 | — | — | EP | disclosed |