Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.33 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.33 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.33 |
| ▸ | STS | P08842 | 1/20 | 0.32 |
| ▸ | MDM2 | Q00987 | 3/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6943048 | 0.88 | MAPT (0.44) | MAPTCYP2C19CYP3A4ALDH1A1CYP2C9 | |
| SCHEMBL6947673 | 0.85 | MAPT (0.42) | MAPTCYP2C19CYP3A4ALDH1A1CYP2C9 | |
| SCHEMBL7239714 | 0.80 | PROKR1 (0.41) | MAPTCYP2C19CYP3A4CYP2C9TSHR | |
| SCHEMBL6954217 | 0.75 | GPR119 (0.36) | ALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL7237312 | 0.75 | POLB (0.30) | L3MBTL1 | |
| SCHEMBL4376967 | 0.71 | ALDH1A1 (0.56) | MAPTCYP2C19CYP3A4ALDH1A1CYP2C9 | |
| SCHEMBL4380104 | 0.69 | ALDH1A1 (0.50) | MAPTCYP2C19CYP3A4ALDH1A1CYP2C9 | |
| SCHEMBL6787059 | 0.68 | MMP13 (0.42) | MAPTCYP3A4ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL6946610 | 0.68 | ALDH1A1 (0.55) | MAPTCYP2C19CYP3A4ALDH1A1CYP2C9 | |
| SCHEMBL4380726 | 0.66 | ALDH1A1 (0.51) | MAPTCYP2C19CYP3A4ALDH1A1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1030836-B1 | HYDROXAMIC AND CARBOXYLIC ACID DERIVATIVES HAVING MMP AND TNF INHIBITORY ACTIVITY | DARWIN DISCOVERY LTD (GB) | 2003-01-29 | — | — | EP | claimed |