Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7239714 | 0.79 | PROKR1 (0.41) | POLBL3MBTL1 | |
| SCHEMBL7238651 | 0.78 | MAPK1 (0.42) | POLBL3MBTL1 | |
| SCHEMBL6787059 | 0.77 | MMP13 (0.42) | POLB | |
| SCHEMBL6952146 | 0.75 | MAPT (0.41) | L3MBTL1 | |
| SCHEMBL6954217 | 0.74 | GPR119 (0.36) | POLBL3MBTL1 | |
| SCHEMBL6347674 | 0.73 | ESR2 (0.38) | — | |
| SCHEMBL6786967 | 0.73 | HDAC1 (0.37) | L3MBTL1 | |
| SCHEMBL6349073 | 0.72 | ESR2 (0.36) | — | |
| SCHEMBL4611345 | 0.70 | CA12 (0.35) | — | |
| SCHEMBL27754048 | 0.66 | LMNA (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6506764-B1 | B-X-(CH2)m-CR1R2-(CH2)n-CO-Y (I) have therapeutic utility as inhibitors of metalloproteinases etc. for medicine by human articular cartilage cells and also involved in the destruction of myelin basic protein, a phenomenon associated with | DARWIN DISCOVERY, LTD. (GB) | 2003-01-14 | — | — | US | disclosed |