Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | MMP8 | P22894 | 3/20 | 0.48 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7374971 | 0.92 | SMN1; SMN2 (0.47) | SMN1; SMN2MAPTMMP8PIN1L3MBTL1 | |
| SCHEMBL7366107 | 0.85 | ALDH1A1 (0.55) | SMN1; SMN2MAPTMMP8PIN1L3MBTL1 | |
| SCHEMBL1856485 | 0.83 | SMN1; SMN2 (0.51) | SMN1; SMN2MAPTMMP8PIN1L3MBTL1 | |
| SCHEMBL11449291 | 0.78 | SMN1; SMN2 (0.49) | SMN1; SMN2MAPTMMP8PIN1L3MBTL1 | |
| SCHEMBL6953006 | 0.78 | KEAP1 (0.48) | SMN1; SMN2MAPTALDH1A1CYP1A2TDP1 | |
| SCHEMBL9531044 | 0.77 | SMN1; SMN2 (0.54) | SMN1; SMN2MAPTMMP8PIN1L3MBTL1 | |
| SCHEMBL4008125 | 0.77 | SMN1; SMN2 (0.49) | SMN1; SMN2MAPTMMP8PIN1L3MBTL1 | |
| SCHEMBL6778466 | 0.77 | MEN1 (0.53) | SMN1; SMN2MAPTMMP8PIN1NPC1 | |
| SCHEMBL935980 | 0.76 | TDP1 (0.59) | SMN1; SMN2MAPTMMP8PIN1L3MBTL1 | |
| SCHEMBL18065697 | 0.76 | SMN1; SMN2 (0.57) | SMN1; SMN2MAPTMMP8PIN1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0729466-A1 | PYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS | PARKE, DAVIS & COMPANY (US) | 1996-09-04 | — | — | EP | disclosed |
| EP-0729465-A1 | PYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS | PARKE, DAVIS & COMPANY (US) | 1996-09-04 | — | — | EP | disclosed |
| WO-1995014013-A1 | PYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS | PARKE, DAVIS & COMPANY (US) | 1995-05-26 | — | — | WO | disclosed |
| WO-1995014014-A2 | PYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS | PARKE, DAVIS & COMPANY (US) | 1995-05-26 | — | — | WO | disclosed |