SCHEMBL6953243

SCHEMBL6953243

O=C(Oc1ccc([N+](=O)[O-])cc1)N1C(=O)O[C@@H](COC2CCCCO2)[C@@H]1c1ccc(F)c(F)c1

nearest known ligand 0.38

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
MGLL Q99685 3/20 0.38
CYP1A2 P05177 1/20 0.36
CYP2D6 P10635 1/20 0.36
FAAH O00519 2/20 0.36
ALDH1A1 P00352 1/20 0.33
HTT P42858 1/20 0.33
ADRA1A P35348 4/20 0.32
ADRA1B P35368 4/20 0.32
ADRA1D P25100 3/20 0.32
HRH1 P35367 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7962594 0.88 CYP1A2 (0.36) MGLLCYP1A2CYP2D6FAAH
SCHEMBL7972575 0.84 MGLL (0.39) MGLLCYP1A2CYP2D6FAAH
SCHEMBL7976298 0.83 ADRA1A (0.38) ADRA1AADRA1BADRA1DHRH1
SCHEMBL7976303 0.83 ADRA1A (0.38) ADRA1AADRA1BADRA1DHRH1
SCHEMBL8173301 0.78 MGLL (0.43) MGLLCYP1A2CYP2D6FAAHALDH1A1
SCHEMBL7966161 0.78 MGLL (0.43) MGLLCYP1A2CYP2D6FAAHALDH1A1
SCHEMBL8174001 0.77 ADRA1A (0.42) MGLLCYP1A2CYP2D6FAAHADRA1A
SCHEMBL5658840 0.77 ADRA1A (0.42) MGLLCYP1A2CYP2D6FAAHADRA1A
SCHEMBL5662288 0.77 ADRA1A (0.42) MGLLCYP1A2CYP2D6FAAHADRA1A
SCHEMBL7747876 0.74 MGLL (0.39) MGLL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0998285-A4 ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS MERCK & CO INC (US) 2003-01-08 EP disclosed
US-6255315-B1 BENIGN PROSTATIC HYPERPLASIA MERCK & CO., INC. 2001-07-03 US disclosed
US-6228870-B1 BENIGN PROSTATIC HYPERPLASIA; REDUCTION OF HYPOTENSION SIDE EFFECT MERCK & CO., INC. 2001-05-08 US disclosed
US-6143750-A NITROGEN HETEROCYCLIC COMPOUNDS AS ENZYME INHIBITORS, FOR PROSTATE PROBLEMS AND MUSCLE RELAXANTS MERCK & CO., INC. (US) 2000-11-07 US disclosed
EP-0998285-A1 ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS Merck & Co., Inc. (US) 2000-05-10 EP disclosed
US-6037354-A ADMINISTERING PHENYL-SUBSTITUTED THIAZOLIDIN-4-ONE OR OXAZOLIDIN-2-ONE DERIVATIVE TO TREAT BENIGN PROSTATE HYPERPLASIA; SIDE EFFECT REDUCTION MERCK & CO., INC. (US) 2000-03-14 US disclosed
WO-1998057641-A1 ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS MERCK & CO., INC. (US) 1998-12-23 WO disclosed