Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 2/20 | 0.48 |
| ▸ | NOS1 | P29475 | 2/20 | 0.48 |
| ▸ | NOS2 | P35228 | 2/20 | 0.48 |
| ▸ | HSPA5 | P11021 | 4/20 | 0.45 |
| ▸ | HSPA2 | P54652 | 2/20 | 0.45 |
| ▸ | HSPA1A | P0DMV8 | 1/20 | 0.45 |
| ▸ | HSPA9 | P38646 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | XBP1 | P17861 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 2/20 | 0.43 |
| ▸ | SCN3A | Q9NY46 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6961584 | 0.90 | EGFR (0.42) | HSPA5HSPA2HSPA1AHSPA9LMNA | |
| SCHEMBL6956947 | 0.87 | FFAR2 (0.53) | HSPA5HSPA2HSPA1AHSPA9LMNA | |
| SCHEMBL6952330 | 0.86 | PKM (0.57) | HSPA5HSPA2HSPA1AHSPA9LMNA | |
| SCHEMBL6952333 | 0.86 | PKM (0.57) | HSPA5HSPA2HSPA1AHSPA9LMNA | |
| SCHEMBL6963268 | 0.80 | SMN1; SMN2 (0.44) | HSPA5HSPA2LMNAALDH1A1PKM | |
| SCHEMBL6963091 | 0.79 | NPC1 (0.51) | HSPA5HSPA2HSPA1AHSPA9LMNA | |
| SCHEMBL6958427 | 0.77 | MEN1 (0.47) | HSPA5LMNAALDH1A1PKMMAPK1 | |
| SCHEMBL6960135 | 0.75 | HSPA1A (0.60) | HSPA5HSPA2HSPA1AHSPA9LMNA | |
| SCHEMBL6960139 | 0.75 | HSPA1A (0.60) | HSPA5HSPA2HSPA1AHSPA9LMNA | |
| SCHEMBL6963168 | 0.75 | ALDH1A1 (0.53) | NOS3NOS1NOS2LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0540143-B1 | Compounds and methods for inhibition of HIV and related viruses | MEDIVIR AB (SE) | 2003-02-05 | — | — | EP | disclosed |
| US-5658907-A | THIOUREA VIRICIDES | MEDIVIR A/B (SE) | 1997-08-19 | — | — | US | disclosed |
| US-5593993-A | VIRICIDES FOR HTLV TREATMENT OF AIDS | MEDIVIR AB (SE) | 1997-01-14 | — | — | US | disclosed |
| EP-0540143-A2 | Compounds and methods for inhibition of HIV and related viruses | Medivir Aktiebolag (SE) | 1993-05-05 | — | — | EP | disclosed |
| WO-1993003022-A1 | COMPOUNDS AND METHODS FOR INHIBITION OF HIV AND RELATED VIRUSES | MEDIVIR AB (SE) | 1993-02-18 | — | — | WO | disclosed |