SCHEMBL6960139

SCHEMBL6960139

O=C(O)C(Cc1ccccc1)NC(=S)Nc1nccs1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSPA1A P0DMV8 1/20 0.60
HSPA5 P11021 1/20 0.60
HSPA9 P38646 1/20 0.60
HSPA2 P54652 1/20 0.60
SMN1; SMN2 Q16637 3/20 0.54
NPC1 O15118 3/20 0.54
RAB9A P51151 3/20 0.54
PKM P14618 2/20 0.54
LMNA P02545 2/20 0.54
MEN1 O00255 1/20 0.54
ALDH1A1 P00352 1/20 0.54
CYP1A2 P05177 1/20 0.54
CYP3A4 P08684 1/20 0.54
GAA P10253 1/20 0.54
CYP2D6 P10635 1/20 0.54
CYP2C9 P11712 1/20 0.54
NFKB1 P19838 1/20 0.54
MAPK1 P28482 1/20 0.54
CYP2C19 P33261 1/20 0.54
THPO P40225 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6960135 1.00 HSPA1A (0.60) HSPA1AHSPA5HSPA9HSPA2SMN1; SMN2
SCHEMBL6952330 0.89 PKM (0.57) HSPA1AHSPA5HSPA9HSPA2SMN1; SMN2
SCHEMBL6952333 0.89 PKM (0.57) HSPA1AHSPA5HSPA9HSPA2SMN1; SMN2
SCHEMBL8687284 0.84 RAB9A (0.58) HSPA1AHSPA5HSPA9HSPA2SMN1; SMN2
SCHEMBL7879989 0.82 HSPA1A (0.58) HSPA1AHSPA5HSPA9HSPA2SMN1; SMN2
SCHEMBL7879986 0.82 HSPA1A (0.58) HSPA1AHSPA5HSPA9HSPA2SMN1; SMN2
SCHEMBL6963164 0.81 NPC1 (0.56) HSPA1AHSPA5HSPA9HSPA2SMN1; SMN2
Hydrochloric Acid SCHEMBL9183800 0.81 HSPA1A (0.57) HSPA1AHSPA5HSPA9HSPA2SMN1; SMN2
SCHEMBL6958345 0.80 LMNA (0.51) HSPA1AHSPA5HSPA9HSPA2SMN1; SMN2
SCHEMBL29687163 0.78 HSPA5 (0.64) HSPA1AHSPA5HSPA9HSPA2SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0540143-B1 Compounds and methods for inhibition of HIV and related viruses MEDIVIR AB (SE) 2003-02-05 EP disclosed