Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.54 |
| ▸ | NPC1 | O15118 | 5/20 | 0.54 |
| ▸ | RAB9A | P51151 | 5/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | MAOB | P27338 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.45 |
| ▸ | RELA | Q04206 | 1/20 | 0.45 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10340370 | 0.81 | ALDH1A1 (0.61) | MAPTNPC1RAB9AALDH1A1KDM4E | |
| SCHEMBL29064508 | 0.81 | TSHR (0.51) | MAPTNPC1RAB9ACYP3A4ALDH1A1 | |
| SCHEMBL11660607 | 0.79 | ERN1 (0.55) | MAPTNPC1RAB9AMAOBMEN1 | |
| SCHEMBL8692154 | 0.79 | TDP1 (0.47) | MAPTNPC1RAB9ACYP1A2CYP3A4 | |
| SCHEMBL13011540 | 0.79 | VCAM1 (0.52) | MAPTNPC1RAB9AALDH1A1MEN1 | |
| SCHEMBL27593939 | 0.78 | ATM (0.50) | MAPTNPC1RAB9AALDH1A1GAA | |
| SCHEMBL15741251 | 0.78 | S100A4 (0.47) | MAPTNPC1RAB9ACYP1A2ALDH1A1 | |
| SCHEMBL38654501 | 0.78 | S100A4 (0.47) | MAPTNPC1RAB9ACYP1A2ALDH1A1 | |
| SCHEMBL99419 | 0.76 | ALDH1A1 (0.57) | MAPTNPC1RAB9ACYP1A2CYP3A4 | |
| SCHEMBL6955307 | 0.76 | ERN1 (0.46) | MAPTNPC1RAB9AALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150247863-A1 | DERIVATIVES OF 1,2-DIHYDRO-7-HYDROXYQUINOLINES CONTAINING FUSED RINGS | Life Technologies Corporation | 2015-09-03 | — | — | US | disclosed |
| US-20150247863-A1 | DERIVATIVES OF 1,2-DIHYDRO-7-HYDROXYQUINOLINES CONTAINING FUSED RINGS | Life Technologies Corporation | 2015-09-03 | — | — | US | disclosed |
| US-20140356873-A1 | Derivatives of 1,2-dihydro-7-hydroxyquinolines Containing Fused Rings | LIFE TECHNOLOGIES CORP (US) | 2014-12-04 | — | — | US | disclosed |
| US-20140356873-A1 | Derivatives of 1,2-dihydro-7-hydroxyquinolines Containing Fused Rings | LIFE TECHNOLOGIES CORP (US) | 2014-12-04 | — | — | US | disclosed |
| US-8846925-B2 | Derivatives of 1,2-dihydro-7-hydroxyquinolines containing fused rings | Life Technologies Corporation (US) | 2014-09-30 | — | — | US | disclosed |
| US-8846925-B2 | Derivatives of 1,2-dihydro-7-hydroxyquinolines containing fused rings | Life Technologies Corporation (US) | 2014-09-30 | — | — | US | disclosed |
| US-20120315661-A1 | Derivatives of 1,2-dihydro-7-hydroxyquinolines Containing Fused Rings | Life Technologies Corporation (US) | 2012-12-13 | — | — | US | disclosed |
| US-20120315661-A1 | Derivatives of 1,2-dihydro-7-hydroxyquinolines Containing Fused Rings | Life Technologies Corporation (US) | 2012-12-13 | — | — | US | disclosed |
| US-8183375-B2 | Derivatives of 1,2-dihydro-7-hydroxyquinolines containing fused rings | Life Technologies Corporation (US) | 2012-05-22 | — | — | US | disclosed |
| US-8183375-B2 | Derivatives of 1,2-dihydro-7-hydroxyquinolines containing fused rings | Life Technologies Corporation (US) | 2012-05-22 | — | — | US | disclosed |
| US-20110027800-A1 | Derivatives of 1,2-dihydro-7-hydroxyquinolines Containing Fused Rings | Life Technologies Corporation (US) | 2011-02-03 | — | — | US | disclosed |
| US-20110027800-A1 | Derivatives of 1,2-dihydro-7-hydroxyquinolines Containing Fused Rings | Life Technologies Corporation (US) | 2011-02-03 | — | — | US | disclosed |
| US-7816519-B2 | longer wavelength absorption than structurally similar dyes; staining; ligand and analyte detection; aromatic or heteroaromatic ring fused at 3,4-double bond; fluorescent dyes, chemically reactive dyes, dye-conjugates; use of such dyes in staining samples and detecting ligands | Life Technologies Corporation (US) | 2010-10-19 | — | — | US | disclosed |
| US-7816519-B2 | longer wavelength absorption than structurally similar dyes; staining; ligand and analyte detection; aromatic or heteroaromatic ring fused at 3,4-double bond; fluorescent dyes, chemically reactive dyes, dye-conjugates; use of such dyes in staining samples and detecting ligands | Life Technologies Corporation (US) | 2010-10-19 | — | — | US | disclosed |
| US-20070093652-A1 | longer wavelength absorption than structurally similar dyes; staining; ligand and analyte detection; aromatic or heteroaromatic ring fused at 3,4-double bond; fluorescent dyes, chemically reactive dyes, dye-conjugates; use of such dyes in staining samples and detecting ligands | INVITROGEN CORPORATION (US) | 2007-04-26 | — | — | US | disclosed |
| US-20070093652-A1 | longer wavelength absorption than structurally similar dyes; staining; ligand and analyte detection; aromatic or heteroaromatic ring fused at 3,4-double bond; fluorescent dyes, chemically reactive dyes, dye-conjugates; use of such dyes in staining samples and detecting ligands | INVITROGEN CORPORATION (US) | 2007-04-26 | — | — | US | disclosed |
| US-7169922-B2 | Longer wavelength absorption than structurally similar dyes; staining; ligand and analyte detection; aromatic or heteroaromatic ring fused at 3,4-double bond | INVITROGEN CORPORATION (US) | 2007-01-30 | — | — | US | disclosed |
| US-7169922-B2 | Longer wavelength absorption than structurally similar dyes; staining; ligand and analyte detection; aromatic or heteroaromatic ring fused at 3,4-double bond | INVITROGEN CORPORATION (US) | 2007-01-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110027800-A1 | Derivatives of 1,2-dihydro-7-hydroxyquinolines Containing Fused Rings | CYP3A7, UGT1A7, UGT2B7 | MAPT 3476/4885NPC1 551/4885RAB9A 2245/4885 |
| US-20070093652-A1 | longer wavelength absorption than structurally similar dyes; staining; ligand and analyte detection; aromatic or heteroaromatic ring fused at 3,4-double bond; fluorescent dyes, chemically reactive dyes, dye-conjugates; use of such dyes in staining samples and detecting ligands | CYP3A4, CYP3A5, UGT1A4 | MAPT 2916/4885NPC1 865/4885RAB9A 2662/4885 |
| US-20150247863-A1 | DERIVATIVES OF 1,2-DIHYDRO-7-HYDROXYQUINOLINES CONTAINING FUSED RINGS | CYP3A7, UGT1A7, UGT2B7 | MAPT 3476/4885NPC1 551/4885RAB9A 2245/4885 |
| US-20140356873-A1 | Derivatives of 1,2-dihydro-7-hydroxyquinolines Containing Fused Rings | CYP3A7, UGT1A7, UGT2B7 | MAPT 3476/4885NPC1 551/4885RAB9A 2245/4885 |
| US-20120315661-A1 | Derivatives of 1,2-dihydro-7-hydroxyquinolines Containing Fused Rings | CYP3A7, UGT1A7, UGT2B7 | MAPT 3476/4885NPC1 551/4885RAB9A 2245/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.