Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 5/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.45 |
| ▸ | TXNRD3 | Q86VQ6 | 1/20 | 0.45 |
| ▸ | TXNRD2 | Q9NNW7 | 1/20 | 0.45 |
| ▸ | ERN1 | O75460 | 1/20 | 0.45 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.43 |
| ▸ | PTPRC | P08575 | 3/20 | 0.43 |
| ▸ | S100A4 | P26447 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11665288 | 0.87 | PTPRC (0.50) | TDP1ALDH1A1SMN1; SMN2TSHRMAPT | |
| SCHEMBL11660607 | 0.84 | ERN1 (0.55) | TDP1MAPTNPC1RAB9AERN1 | |
| SCHEMBL27287105 | 0.83 | ALDH1A1 (0.51) | TDP1ALDH1A1SMN1; SMN2TSHRMAPT | |
| SCHEMBL29064508 | 0.83 | TSHR (0.51) | ALDH1A1SMN1; SMN2GPR35HPGDTSHR | |
| SCHEMBL38654501 | 0.83 | S100A4 (0.47) | TDP1ALDH1A1SMN1; SMN2HPGDMAPT | |
| SCHEMBL27593939 | 0.83 | ATM (0.50) | TDP1ALDH1A1SMN1; SMN2MAPTNPC1 | |
| SCHEMBL15741251 | 0.83 | S100A4 (0.47) | TDP1ALDH1A1SMN1; SMN2HPGDMAPT | |
| SCHEMBL5913033 | 0.80 | ERN1 (0.51) | ALDH1A1SMN1; SMN2HPGDMAPTNPC1 | |
| SCHEMBL331601 | 0.80 | ALDH1A1 (0.53) | TDP1ALDH1A1SMN1; SMN2TP53HPGD | |
| SCHEMBL7201063 | 0.79 | ALDH1A1 (0.59) | TDP1ALDH1A1SMN1; SMN2GPR35TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3013808-B1 | ISOTHIAZOLINE COMPOUNDS SUBSTITUTED WITH A CARBOBICYCLIC GROUP | BOEHRINGER INGELHEIM ANIMAL HEALTH USA INC (US) | 2020-04-15 | — | — | EP | disclosed |
| EP-3013807-B1 | NAPHTHYL-SUBSTITUTED ISOTHIAZOLINE COMPOUNDS | BOEHRINGER INGELHEIM ANIMAL HEALTH USA INC (US) | 2020-04-08 | — | — | EP | disclosed |
| US-10327446-B2 | Naphthyl- or isoquinolinyl-substituted isothiazoline compounds | Boehringer Ingelheim Animal Health USA Inc. (US) | 2019-06-25 | — | — | US | disclosed |
| EP-2794601-B1 | ISOTHIAZOLINE COMPOUNDS FOR COMBATING INVERTEBRATE PESTS | BASF SE (DE) | 2019-02-20 | — | — | EP | disclosed |
| EP-3013822-B1 | THIOPHENE- OR FURAN-SUBSTITUTED ISOTHIAZOLINE COMPOUNDS AS PESTICIDES | MERIAL INC (US) | 2017-11-01 | — | — | EP | disclosed |
| US-9732051-B2 | Isothiazoline compounds for combating invertebrate pests | BASF SE (DE) | 2017-08-15 | — | — | US | disclosed |
| US-20160374342-A1 | Naphthyl- or isoquinolinyl-substituted isothiazoline compounds | MERIAL, INC. (US) | 2016-12-29 | — | — | US | disclosed |
| US-20160297808-A1 | Thiophene- or furan-substituted isothiazoline Compounds as Pesticides | MERIAL, INC. (US) | 2016-10-13 | — | — | US | disclosed |
| US-20160145223-A1 | Bicyclyl-Substituted Isothiazoline Compounds | BASF SE (DE) | 2016-05-26 | — | — | US | disclosed |
| EP-3013820-A1 | BICYCLYL-SUBSTITUTED ISOTHIAZOLINE COMPOUNDS | BASF SE (DE) | 2016-05-04 | — | — | EP | disclosed |
| WO-2014206909-A1 | THIOPHENE- OR FURAN-SUBSTITUTED ISOTHIAZOLINE COMPOUNDS AS PESTICIDES | BASF SE (DE) | 2014-12-31 | — | — | WO | disclosed |
| WO-2014206908-A1 | ISOTHIAZOLINE COMPOUNDS SUBSTITUTED WITH A CARBOBICYCLIC GROUP | BASF SE (DE) | 2014-12-31 | — | — | WO | disclosed |
| WO-2014206910-A1 | BICYCLYL-SUBSTITUTED ISOTHIAZOLINE COMPOUNDS | BASF SE (DE) | 2014-12-31 | — | — | WO | disclosed |
| WO-2014206907-A1 | NAPHTHYL- OR ISOQUINOLINYL-SUBSTITUTED ISOTHIAZOLINE COMPOUNDS | BASF SE (DE) | 2014-12-31 | — | — | WO | disclosed |
| WO-2014206911-A1 | ISOTHIAZOLINE COMPOUNDS FOR COMBATING INVERTEBRATE PESTS | BASF SE (DE) | 2014-12-31 | — | — | WO | disclosed |
| US-20140364466-A1 | Isothiazoline compounds for combating invertebrate pests | BASF SE (DE) | 2014-12-11 | — | — | US | disclosed |
| EP-2794601-A1 | ISOTHIAZOLINE COMPOUNDS FOR COMBATING INVERTEBRATE PESTS | BASF SE (DE) | 2014-10-29 | — | — | EP | disclosed |
| WO-2013092943-A1 | ISOTHIAZOLINE COMPOUNDS FOR COMBATING INVERTEBRATE PESTS | BASF SE (DE) | 2013-06-27 | — | — | WO | disclosed |
| US-5719292-A | REACTING IN PRESENCE OF BASE COUPLER COMPOUND HAVING HYDROGEN AT COUPLING SITE AND MIXED DISULFIDE COMPRISING TETRAZOLE OR OXADIAZOLE LINKED TO ONE SULFUR ATOM AND ALKYL OR ARYL GROUP LINKED TO OTHER | EASTMAN KODAK COMPANY (US) | 1998-02-17 | — | — | US | disclosed |
| US-4119629-A | CENTRAL NERVOUS SYSTEM DEPRESSANTS, WEIGHT CONTROL AGENTS | MILLER RICHARD FOSTER | 1978-10-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160145223-A1 | Bicyclyl-Substituted Isothiazoline Compounds | BROX, TUBA3C, SYMPK | TDP1 1228/4885ALDH1A1 2335/4885SMN1; SMN2 1752/4885 |
| US-20160297808-A1 | Thiophene- or furan-substituted isothiazoline Compounds as Pesticides | PTMS, DDT, PIR | TDP1 373/4885ALDH1A1 1576/4885SMN1; SMN2 3064/4885 |
| US-20160374342-A1 | Naphthyl- or isoquinolinyl-substituted isothiazoline compounds | IPO5, SNX1, IPO9 | TDP1 1498/4885ALDH1A1 3018/4885SMN1; SMN2 2115/4885 |
| US-10327446-B2 | Naphthyl- or isoquinolinyl-substituted isothiazoline compounds | IPO5, SNX1, IPO9 | TDP1 1498/4885ALDH1A1 3018/4885SMN1; SMN2 2115/4885 |
| US-20140364466-A1 | Isothiazoline compounds for combating invertebrate pests | PIR, ACHE, INMT | TDP1 955/4885ALDH1A1 2079/4885SMN1; SMN2 2187/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.