Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 3/20 | 0.52 |
| ▸ | GSK3B | P49841 | 1/20 | 0.50 |
| ▸ | PIM1 | P11309 | 3/20 | 0.48 |
| ▸ | PIM2 | Q9P1W9 | 3/20 | 0.48 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.48 |
| ▸ | IGF1R | P08069 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 6/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6956100 | 1.00 | PPARG (0.52) | PPARGGSK3BPIM1PIM2PIM3 | |
| SCHEMBL1249857 | 0.80 | GSK3B (0.60) | PPARGGSK3BPIM1PIM2PIM3 | |
| SCHEMBL1249852 | 0.80 | GSK3B (0.60) | PPARGGSK3BPIM1PIM2PIM3 | |
| SCHEMBL6958945 | 0.79 | CRHBP (0.42) | MEN1KMT2ANPC1RAB9A | |
| SCHEMBL6956103 | 0.79 | MAOA (0.48) | PPARGPIM1PIM2PIM3IGF1R | |
| SCHEMBL6964865 | 0.73 | PPARG (0.49) | PPARGMAOA | |
| SCHEMBL9327162 | 0.70 | PPARG (0.80) | PPARGPIM1PIM2HPGDPTPN1 | |
| SCHEMBL9327166 | 0.70 | PPARG (0.80) | PPARGPIM1PIM2HPGDPTPN1 | |
| SCHEMBL6958317 | 0.70 | CRHBP (0.40) | MEN1KMT2A | |
| SCHEMBL6184718 | 0.70 | PPARG (0.52) | PPARGGSK3BPIM1PIM2PIM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0787725-B1 | QUINOLINE DERIVATIVE | NIPPON CHEMIPHAR CO (JP) | 2003-04-23 | — | — | EP | disclosed |
| EP-0787725-A1 | QUINOLINE DERIVATIVE | NIPPON CHEMIPHAR CO., LTD. (JP) | 1997-08-06 | — | — | EP | disclosed |