Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HTR4 | Q13639 | 2/20 | 0.33 |
| ▸ | CNR1 | P21554 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | DRD5 | P21918 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.33 |
| ▸ | HTR1D | P28221 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7749161 | 0.81 | HTR4 (0.45) | HTR4LMNACHRM2HTR1AADRA2A | |
| SCHEMBL8309066 | 0.75 | HTR4 (0.46) | HTR4LMNACHRM2CHRM4HTR1A | |
| SCHEMBL8366393 | 0.73 | NOTUM (0.41) | SMN1; SMN2ALDH1A1MAPTPRKDC | |
| SCHEMBL8368942 | 0.72 | HTR4 (0.38) | HTR4CNR1LMNACHRM2CHRM4 | |
| SCHEMBL8364679 | 0.71 | CNR1 (0.36) | HTR4CNR1GPR55FAAH | |
| SCHEMBL7749150 | 0.69 | MDM2 (0.37) | HTR4CNR1MAPTGPR55 | |
| SCHEMBL8308257 | 0.68 | NR3C1 (0.39) | HTR4CNR1MAPTGPR55 | |
| SCHEMBL7799596 | 0.68 | HTR4 (0.36) | HTR4LMNACHRM2CHRM4HTR1A | |
| SCHEMBL6956244 | 0.67 | FSCN1 (0.33) | HTR4CNR1GPR55CYP2C9 | |
| SCHEMBL8365005 | 0.66 | CNR1 (0.37) | CNR1GPR55CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0980368-B1 | 3-(PYRROLIDIN-3-YL)-1,3,4-OXADIAZOL-2(3H)-ONE DERIVATIVES AND THEIR USE AS 5-HT4 LIGANDS | SANOFI SYNTHELABO (FR) | 2003-10-22 | — | — | EP | disclosed |
| US-6248757-B1 | ANTISEROTONINE AGENTS | SANOFI-SYNTHELABO (FR) | 2001-06-19 | — | — | US | disclosed |