Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | EIF4E | P06730 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | MGAM | O43451 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | SI | P14410 | 1/20 | 0.42 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GUSB | P08236 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | F2 | P00734 | 1/20 | 0.41 |
| ▸ | C1R | P00736 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | DDX3X | O00571 | 1/20 | 0.41 |
| ▸ | FABP3 | P05413 | 1/20 | 0.40 |
| ▸ | FABP4 | P15090 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6956134 | 1.00 | TDP1 (0.53) | TDP1L3MBTL1ALDH1A1TSHREIF4E | |
| SCHEMBL29383650 | 0.91 | KMT2A (0.49) | TDP1L3MBTL1ALDH1A1TSHREIF4E | |
| SCHEMBL6949727 | 0.91 | KMT2A (0.49) | TDP1L3MBTL1ALDH1A1TSHREIF4E | |
| SCHEMBL2636596 | 0.91 | KMT2A (0.49) | TDP1L3MBTL1ALDH1A1TSHREIF4E | |
| SCHEMBL8412555 | 0.88 | TDP1 (0.44) | TDP1L3MBTL1ALDH1A1TSHRHSD17B10 | |
| SCHEMBL7084528 | 0.85 | TDP1 (0.42) | TDP1L3MBTL1ALDH1A1TSHREIF4E | |
| SCHEMBL29684128 | 0.85 | ALDH1A1 (0.44) | TDP1L3MBTL1ALDH1A1TSHRGAA | |
| SCHEMBL29351076 | 0.85 | ALDH1A1 (0.48) | TDP1ALDH1A1TSHRHSD17B10GAA | |
| SCHEMBL744307 | 0.85 | ALDH1A1 (0.48) | TDP1ALDH1A1TSHRHSD17B10GAA | |
| SCHEMBL9570762 | 0.85 | MAPT (0.42) | TDP1L3MBTL1ALDH1A1HSD17B10MGAM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3408266-B1 | N3,N6-BIS(2-(5-METHOXY-1H-INDOLE-3-YL)ETHYL)-2,6-DIMETHYL-4-(2-NITROPHENYL)PYRIDINE-3,5-DICARBOXAMIDE AND USE THEREOF IN THE FIELD OF NEUROTOXICITY | ATATUERK UENIVERSITESI BILIMSEL ARASTIRMA PROJELERI BIRIMI (TR) | 2020-11-18 | — | — | EP | claimed |
| EP-1023267-B1 | PYRIDYL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | CERMOL SA (CH) | 2003-09-17 | — | — | EP | claimed |
| EP-3408266-B1 | N3,N6-BIS(2-(5-METHOXY-1H-INDOLE-3-YL)ETHYL)-2,6-DIMETHYL-4-(2-NITROPHENYL)PYRIDINE-3,5-DICARBOXAMIDE AND USE THEREOF IN THE FIELD OF NEUROTOXICITY | ATATUERK UENIVERSITESI BILIMSEL ARASTIRMA PROJELERI BIRIMI (TR) | 2020-11-18 | — | — | EP | disclosed |
| US-10758521-B2 | N3,N6-bis(2-(5-methoxy-1H-indole-3-yl)ethyl)-2,6-dimethyl-4-(2-nitrophenyl)pyridine-3,5-dicarboxamide and use thereof in the field of neurotoxicity | HCM BIOSCIENCE SAGLIK TEKNOLOJILERI ANONIM SIRKETI (TR) | 2020-09-01 | — | — | US | disclosed |
| US-10576072-B2 | N3,N6-bis(2-(5-methoxy-1H-indole-3-yl)ethyl)-2,6-dimethyl-4-(2-nitrophenyl)pyridine-3,5-dicarboxamide and use thereof in the field of neurotoxicity | HCM BIOSCIENCE SAGLIK TEKNOLOJILERI ANONIM SIRKETI (TR) | 2020-03-03 | — | — | US | disclosed |
| US-20190290628-A1 | N3,N6-BIS(2-(5-METHOXY-1H-INDOLE-3-YL)ETHYL)-2,6-DIMETHYL-4-(2-NITROPHENYL)PYRIDINE-3,5-DICARBOXAMIDE AND USE THEREOF IN THE FIELD OF NEUROTOXICITY | HCM BIOSCIENCE SAGLIK TEKNOLOJILERI ANONIM SIRKETI (TR) | 2019-09-26 | — | — | US | disclosed |
| US-20190038612-A1 | N3,N6-BIS(2-(5-METHOXY-1H-INDOLE-3-YL)ETHYL)-2,6-DIMETHYL-4-(2-NITROPHENYL)PYRIDINE-3,5-DICARBOXAMIDE AND USE THEREOF IN THE FIELD OF NEUROTOXICITY | HCM BIOSCIENCE SAGLIK TEKNOLOJILERI ANONIM SIRKETI (TR) | 2019-02-07 | — | — | US | disclosed |
| EP-3408266-A1 | N3,N6-BIS(2-(5-METHOXY-1H-INDOLE-3-YL)ETHYL)-2,6-DIMETHYL-4-(2-NITROPHENYL)PYRIDINE-3,5-DICARBOXAMIDE AND USE THEREOF IN THE FIELD OF NEUROTOXICITY | Atatürk Üniversitesi Bilimsel Arastirma Projeleri Birimi (TR) | 2018-12-05 | — | — | EP | disclosed |
| WO-2017131601-A1 | N3,N6-BIS(2-(5-METHOXY-1H-INDOLE-3-YL)ETHYL)-2,6-DIMETHYL-4-(2-NITROPHENYL)PYRIDINE-3,5-DICARBOXAMIDE AND USE THEREOF IN THE FIELD OF NEUROTOXICITY | ATATURK UNIVERSITESI BILIMSEL ARASTIRMA PROJELERI BIRIMI (TR) | 2017-08-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190290628-A1 | N3,N6-BIS(2-(5-METHOXY-1H-INDOLE-3-YL)ETHYL)-2,6-DIMETHYL-4-(2-NITROPHENYL)PYRIDINE-3,5-DICARBOXAMIDE AND USE THEREOF IN THE FIELD OF NEUROTOXICITY | NLN, CASP3, AANAT | TDP1 358/4885L3MBTL1 83/4885ALDH1A1 564/4885 |
| US-10576072-B2 | N3,N6-bis(2-(5-methoxy-1H-indole-3-yl)ethyl)-2,6-dimethyl-4-(2-nitrophenyl)pyridine-3,5-dicarboxamide and use thereof in the field of neurotoxicity | NLN, CASP3, AANAT | TDP1 358/4885L3MBTL1 83/4885ALDH1A1 564/4885 |
| US-20190038612-A1 | N3,N6-BIS(2-(5-METHOXY-1H-INDOLE-3-YL)ETHYL)-2,6-DIMETHYL-4-(2-NITROPHENYL)PYRIDINE-3,5-DICARBOXAMIDE AND USE THEREOF IN THE FIELD OF NEUROTOXICITY | NLN, CASP3, AANAT | TDP1 358/4885L3MBTL1 83/4885ALDH1A1 564/4885 |
| US-10758521-B2 | N3,N6-bis(2-(5-methoxy-1H-indole-3-yl)ethyl)-2,6-dimethyl-4-(2-nitrophenyl)pyridine-3,5-dicarboxamide and use thereof in the field of neurotoxicity | NLN, CASP3, AANAT | TDP1 358/4885L3MBTL1 83/4885ALDH1A1 564/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.