SCHEMBL6956259

SCHEMBL6956259

O=C(O)COc1ccc(-c2cc(O)c(SCCc3ccccc3)c(=O)o2)cc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
XDH P47989 1/20 0.48
AKR1C3 P42330 1/20 0.43
AKR1C2 P52895 1/20 0.43
AKR1C1 Q04828 1/20 0.43
ABL1 P00519 1/20 0.42
PPARD Q03181 2/20 0.41
PPARG P37231 1/20 0.41
SMN1; SMN2 Q16637 2/20 0.41
HPGD P15428 2/20 0.41
ALDH1A1 P00352 1/20 0.41
KDM5A P29375 1/20 0.41
PPARA Q07869 1/20 0.40
ALOX15 P16050 1/20 0.40
POLB P06746 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.39
ABCB1 P08183 2/20 0.39
MAPT P10636 1/20 0.39
NPSR1 Q6W5P4 1/20 0.39
PLA2G4A P47712 1/20 0.39
ABCG2 Q9UNQ0 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6959585 0.90 FABP4 (0.45) XDHAKR1C3AKR1C2AKR1C1ABL1
SCHEMBL6952547 0.89 ABCB1 (0.50) L3MBTL1ABCB1MAPT
SCHEMBL6956331 0.89 SLC16A3 (0.46) L3MBTL1ABCB1MAPT
SCHEMBL6960907 0.88 ACHE (0.42) XDHSMN1; SMN2ALDH1A1POLBL3MBTL1
SCHEMBL6958378 0.88 MAOA (0.45) XDHABCB1
SCHEMBL8434646 0.88 KDM4E (0.54) HPGDALDH1A1KDM5APOLBMAPT
SCHEMBL6957097 0.87 CYSLTR1 (0.41) SMN1; SMN2POLBL3MBTL1ABCB1MAPT
SCHEMBL6963318 0.85 CYP1A1 (0.38) ABL1SMN1; SMN2HPGDALDH1A1POLB
SCHEMBL6954657 0.85 SMN1; SMN2 (0.44) XDHSMN1; SMN2HPGDALDH1A1ALOX15
SCHEMBL6960622 0.85 SMN1; SMN2 (0.49) XDHABL1PPARGSMN1; SMN2HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0729466-A1 PYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS PARKE, DAVIS & COMPANY (US) 1996-09-04 EP claimed
WO-1995014014-A2 PYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS PARKE, DAVIS & COMPANY (US) 1995-05-26 WO claimed
EP-0729465-B1 PYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS PARKE DAVIS & CO (US) 2003-01-22 EP disclosed
US-6005103-A TREATMENT OF BACTERIAL AND VIRAL INFECTIONS AND DISEASES, INCLUDING AIDS WARNER-LAMBERT COMPANY (US) 1999-12-21 US disclosed
EP-0729466-A1 PYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS PARKE, DAVIS & COMPANY (US) 1996-09-04 EP disclosed
EP-0729465-A1 PYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS PARKE, DAVIS & COMPANY (US) 1996-09-04 EP disclosed
WO-1995014013-A1 PYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS PARKE, DAVIS & COMPANY (US) 1995-05-26 WO disclosed
WO-1995014014-A2 PYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS PARKE, DAVIS & COMPANY (US) 1995-05-26 WO disclosed