Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.54 |
| ▸ | HPGD | P15428 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | KDM5A | P29375 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 10/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6956259 | 0.88 | XDH (0.48) | HPGDALDH1A1MAPTPOLBKDM5A | |
| SCHEMBL6952530 | 0.84 | TNKS (0.53) | KDM4EHPGDALDH1A1MAPTHSD17B10 | |
| SCHEMBL6952547 | 0.84 | ABCB1 (0.50) | MAPTCYP1A2CYP2C19PTPN1 | |
| SCHEMBL6956331 | 0.84 | SLC16A3 (0.46) | MAPT | |
| SCHEMBL6958378 | 0.83 | MAOA (0.45) | — | |
| SCHEMBL6960907 | 0.83 | ACHE (0.42) | ALDH1A1MAPTPOLBGAA | |
| SCHEMBL6957097 | 0.82 | CYSLTR1 (0.41) | MAPTPOLBPTPN1 | |
| SCHEMBL6963318 | 0.81 | CYP1A1 (0.38) | KDM4EHPGDALDH1A1MAPTHSD17B10 | |
| SCHEMBL6954657 | 0.80 | SMN1; SMN2 (0.44) | KDM4EHPGDALDH1A1MAPTTP53 | |
| SCHEMBL6960622 | 0.80 | SMN1; SMN2 (0.49) | KDM4EHPGDALDH1A1MAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6005103-A | TREATMENT OF BACTERIAL AND VIRAL INFECTIONS AND DISEASES, INCLUDING AIDS | WARNER-LAMBERT COMPANY (US) | 1999-12-21 | — | — | US | disclosed |
| EP-0729466-A1 | PYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS | PARKE, DAVIS & COMPANY (US) | 1996-09-04 | — | — | EP | disclosed |
| WO-1995014014-A2 | PYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS | PARKE, DAVIS & COMPANY (US) | 1995-05-26 | — | — | WO | disclosed |