Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.54 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.51 |
| ▸ | TRPV6 | Q9H1D0 | 3/20 | 0.49 |
| ▸ | FUCA1 | P04066 | 2/20 | 0.49 |
| ▸ | SLC18A3 | Q16572 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | CCR5 | P51681 | 1/20 | 0.46 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11558271 | 0.86 | FUCA1 (0.60) | SIGMAR1FUCA1SLC18A3ALDH1A1CCR5 | |
| SCHEMBL11558275 | 0.86 | FUCA1 (0.60) | SIGMAR1FUCA1SLC18A3ALDH1A1CCR5 | |
| SCHEMBL11558282 | 0.86 | FUCA1 (0.60) | SIGMAR1FUCA1SLC18A3ALDH1A1CCR5 | |
| SCHEMBL8844573 | 0.84 | TP53 (0.59) | TP53MDM2SIGMAR1TRPV6CCR5 | |
| SCHEMBL2569983 | 0.80 | TRPV6 (0.64) | TP53MDM2SIGMAR1TRPV6CCR5 | |
| SCHEMBL6042249 | 0.79 | ACHE (0.56) | FUCA1SLC18A3ALDH1A1HTT | |
| SCHEMBL6041336 | 0.78 | DRD2 (0.67) | SIGMAR1FUCA1SLC18A3ALDH1A1HTT | |
| SCHEMBL6041900 | 0.77 | ACHE (0.55) | FUCA1SLC18A3ALDH1A1HTT | |
| SCHEMBL6041781 | 0.77 | SLC18A3 (0.58) | SIGMAR1FUCA1SLC18A3ALDH1A1 | |
| SCHEMBL6043310 | 0.77 | FUCA1 (0.53) | SIGMAR1FUCA1SLC18A3ALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863875-B1 | NEW 4-(OXYALKOXYPHENYL)-3-OXY-PIPERIDINES FOR TREATING HEART AND KIDNEY INSUFFICIENCY | HOFFMANN LA ROCHE (CH) | 2003-06-04 | — | — | EP | disclosed |
| US-6150526-A | Piperidine derivative having renin inhibiting activity | HOFFMANN-LA ROCHE INC. (US) | 2000-11-21 | — | — | US | disclosed |
| US-6051712-A | PREVENTION OF HIGH BLOOD PRESSURE AND CARDIAC INSUFFICIENCY, AS WELL AS GLAUCOMA, CARDIAC INFARCT, KIDNEY INSUFFICIENCY AND RESTENOSIS | HOFFMANN-LA ROCHE INC. (US) | 2000-04-18 | — | — | US | disclosed |