SCHEMBL6956643

SCHEMBL6956643

CCCc1nc(OC)c(NC(=S)Oc2ccccc2)cc1C

nearest known ligand 0.35

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 5/20 0.33
ALDH1A1 P00352 4/20 0.33
MAPT P10636 4/20 0.33
HTT P42858 2/20 0.33
TAAR1 Q96RJ0 1/20 0.33
LMNA P02545 2/20 0.32
CYP1A2 P05177 1/20 0.32
CYP3A4 P08684 1/20 0.32
ALOX12 P18054 1/20 0.32
CYP2C19 P33261 1/20 0.32
HPGD P15428 2/20 0.32
TP53 P04637 1/20 0.31
GAA P10253 2/20 0.31
POLB P06746 2/20 0.31
MEN1 O00255 1/20 0.31
KMT2A Q03164 1/20 0.31
HDAC6 Q9UBN7 1/20 0.31
L3MBTL1 Q9Y468 1/20 0.31
MAPKAPK2 P49137 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6956239 0.86 ALDH1A1 (0.43) SMN1; SMN2ALDH1A1MAPTHTTHPGD
SCHEMBL6960156 0.84 ALDH1A1 (0.32) SMN1; SMN2ALDH1A1MAPTLMNAALOX12
SCHEMBL6962164 0.83 MAPT (0.35) SMN1; SMN2ALDH1A1MAPTHTTCYP1A2
SCHEMBL8699464 0.79 MAPT (0.37) SMN1; SMN2ALDH1A1MAPTLMNAPOLB
SCHEMBL6956640 0.77 L3MBTL1 (0.39) SMN1; SMN2ALDH1A1MAPTHTTTAAR1
SCHEMBL6956452 0.77 ALDH1A1 (0.44) SMN1; SMN2ALDH1A1MAPTHTTCYP1A2
SCHEMBL6956523 0.76 RAB9A (0.40) SMN1; SMN2ALDH1A1MAPTCYP1A2CYP3A4
SCHEMBL6956205 0.74 SMN1; SMN2 (0.43) SMN1; SMN2ALDH1A1MAPTHTTCYP1A2
SCHEMBL6958260 0.72 PHGDH (0.55) ALDH1A1HTTLMNACYP3A4CYP2C19
SCHEMBL6954174 0.72 ALDH1A1 (0.45) SMN1; SMN2ALDH1A1MAPTHTTTAAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0850222-B1 PIPERAZINE DERIVATIVES AND PROCESS FOR THE PREPARATION THEREOF SAMJIN PHARM CO LTD (KR) 2003-05-28 EP disclosed
US-6028195-A AN ANTITUMOR AGENT WITH VERY LOW TOXICITIES SAMJIN PHARMACEUTICAL CO., LTD. (KR) 2000-02-22 US disclosed
EP-0850222-A1 PIPERAZINE DERIVATIVES AND PROCESS FOR THE PREPARATION THEREOF Samjin Pharmaceutical Co., Ltd. (KR) 1998-07-01 EP disclosed
WO-1998000402-A1 PIPERAZINE DERIVATIVES AND PROCESS FOR THE PREPARATION THEREOF SAMJIN PHARMACEUTICAL CO., LTD. (KR) 1998-01-08 WO disclosed