SCHEMBL6960156

SCHEMBL6960156

CCCc1cc(NC(=S)Oc2ccccc2)c(OC)nc1C

nearest known ligand 0.33

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.32
KMT2A Q03164 2/20 0.32
MEN1 O00255 1/20 0.32
MAPT P10636 5/20 0.32
SMN1; SMN2 Q16637 2/20 0.32
LMNA P02545 1/20 0.32
HPGD P15428 2/20 0.32
MTNR1A P48039 2/20 0.31
MTNR1B P49286 2/20 0.31
KDM4E B2RXH2 1/20 0.31
GAA P10253 1/20 0.31
POLB P06746 1/20 0.31
MAPKAPK2 P49137 1/20 0.31
FAAH O00519 1/20 0.31
RAB9A P51151 1/20 0.31
ALOX12 P18054 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8699464 0.91 MAPT (0.37) ALDH1A1KMT2AMEN1MAPTSMN1; SMN2
SCHEMBL6966654 0.86 ALDH1A1 (0.43) ALDH1A1KMT2AMEN1MAPTSMN1; SMN2
SCHEMBL6956643 0.84 SMN1; SMN2 (0.33) ALDH1A1KMT2AMEN1MAPTSMN1; SMN2
SCHEMBL6962164 0.83 MAPT (0.35) ALDH1A1KMT2AMEN1MAPTSMN1; SMN2
SCHEMBL8594445 0.79 GRM1 (0.37) ALDH1A1KMT2AMEN1MAPTSMN1; SMN2
SCHEMBL6956205 0.78 SMN1; SMN2 (0.43) ALDH1A1MAPTSMN1; SMN2HPGDKDM4E
SCHEMBL6953240 0.78 KMT2A (0.46) ALDH1A1KMT2AMEN1MAPTSMN1; SMN2
SCHEMBL6960150 0.76 MAPT (0.35) ALDH1A1MAPTSMN1; SMN2KDM4EGAA
SCHEMBL6956523 0.76 RAB9A (0.40) ALDH1A1KMT2AMEN1MAPTSMN1; SMN2
SCHEMBL6561301 0.74 KMT2A (0.36) ALDH1A1KMT2AMEN1MAPTSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0850222-B1 PIPERAZINE DERIVATIVES AND PROCESS FOR THE PREPARATION THEREOF SAMJIN PHARM CO LTD (KR) 2003-05-28 EP disclosed
US-6028195-A AN ANTITUMOR AGENT WITH VERY LOW TOXICITIES SAMJIN PHARMACEUTICAL CO., LTD. (KR) 2000-02-22 US disclosed
EP-0850222-A1 PIPERAZINE DERIVATIVES AND PROCESS FOR THE PREPARATION THEREOF Samjin Pharmaceutical Co., Ltd. (KR) 1998-07-01 EP disclosed
WO-1998000402-A1 PIPERAZINE DERIVATIVES AND PROCESS FOR THE PREPARATION THEREOF SAMJIN PHARMACEUTICAL CO., LTD. (KR) 1998-01-08 WO disclosed