Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.35 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.35 |
| ▸ | LCK | P06239 | 1/20 | 0.33 |
| ▸ | FYN | P06241 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | TPMT | P51580 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | LIG1 | P18858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6201000 | 0.76 | GSK3B (0.41) | PKM | |
| SCHEMBL6924925 | 0.73 | KEAP1 (0.57) | KEAP1NFE2L2LCKFYNPKM | |
| SCHEMBL9158487 | 0.73 | DAO (0.34) | — | |
| SCHEMBL6970016 | 0.72 | ALDH1A1 (0.41) | — | |
| SCHEMBL6923952 | 0.69 | KEAP1 (0.41) | KEAP1NFE2L2TSHRHSD17B10PKM | |
| SCHEMBL5046977 | 0.66 | GPR35 (0.33) | — | |
| SCHEMBL9176677 | 0.66 | MAPT (0.52) | HSD17B10 | |
| SCHEMBL5200748 | 0.64 | CHRNA1 (0.39) | HSD17B10 | |
| SCHEMBL5202302 | 0.63 | SLC9A1 (0.48) | — | |
| SCHEMBL10882465 | 0.63 | DAO (0.55) | TSHRHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0676395-B1 | Substituted N-heteroaroylguanidines, as inhibitors of sodium-hydrogen exchange, as antiarrhythmic agents and as inhibitors of the proliferation of cells | HOECHST AG (DE) | 2003-09-03 | — | — | EP | disclosed |
| EP-0676395-A2 | Substituted N-heteroaroylguanidines, as inhibitors of sodium-hydrogen exchange, as antiarrhythmic agents and as inhibitors of the proliferation of cells | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-10-11 | — | — | EP | disclosed |