Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | KEAP1 | Q14145 | 3/20 | 0.36 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.35 |
| ▸ | RELA | Q04206 | 1/20 | 0.35 |
| ▸ | CCR5 | P51681 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6953646 | 0.88 | MCHR1 (0.45) | SRCMCHR1MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL25606805 | 0.86 | SRC (0.41) | SRCMAPTALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL8092415 | 0.84 | BRD4 (0.39) | MCHR1MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL6952817 | 0.81 | ADRA2A (0.48) | MCHR1SMN1; SMN2MEN1KMT2AKDM4E | |
| SCHEMBL6949352 | 0.81 | AKR1C2 (0.47) | MCHR1ALDH1A1SMN1; SMN2ALOX15KDM4E | |
| SCHEMBL6951250 | 0.79 | PSEN1 (0.40) | ALDH1A1MEN1KMT2AKDM4EPTGDR2 | |
| SCHEMBL7294400 | 0.77 | HTR1A (0.44) | MCHR1GAA | |
| SCHEMBL27500544 | 0.76 | HTR1A (0.34) | MCHR1 | |
| SCHEMBL10352783 | 0.72 | CCR5 (0.39) | MAPTALDH1A1SMN1; SMN2ALOX15KDM4E | |
| SCHEMBL11459982 | 0.72 | MCHR1 (0.45) | MCHR1KEAP1NFE2L2PTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1010693-B1 | Imidazoline derivatives, preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2003-09-24 | — | — | EP | disclosed |
| EP-1010693-A1 | Imidazoline derivatives, preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 2000-06-21 | — | — | EP | disclosed |