Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C2 | P52895 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.47 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.47 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | RXRA | P19793 | 1/20 | 0.40 |
| ▸ | RXRB | P28702 | 1/20 | 0.40 |
| ▸ | RXRG | P48443 | 1/20 | 0.40 |
| ▸ | AR | P10275 | 2/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11469458 | 0.89 | CYP11B1 (0.48) | AKR1C2HSD17B10PTGS1AKR1C3CYP11B2 | |
| SCHEMBL7305935 | 0.87 | MTNR1A (0.43) | CYP11B2MTNR1AKDM4EALDH1A1HPGD | |
| SCHEMBL8096734 | 0.85 | PPARG (0.42) | HSD17B10CYP11B2MTNR1AKDM4EALDH1A1 | |
| SCHEMBL6958447 | 0.81 | SRC (0.40) | KDM4EALDH1A1SMN1; SMN2PTGDR2MCHR1 | |
| SCHEMBL8533789 | 0.79 | CYP11B2 (0.45) | CYP11B2MTNR1AALOX5 | |
| SCHEMBL7071372 | 0.79 | PPARG (0.41) | MTNR1AALDH1A1HPGD | |
| SCHEMBL8483356 | 0.78 | CYP11B2 (0.46) | HSD17B10PTGS1CYP11B2MTNR1AKDM4E | |
| SCHEMBL6952817 | 0.78 | ADRA2A (0.48) | KDM4ESMN1; SMN2PTGDR2MCHR1RXRA | |
| SCHEMBL11282142 | 0.75 | CYP11B2 (0.44) | HSD17B10CYP11B2MTNR1ATSHR | |
| SCHEMBL6951250 | 0.75 | PSEN1 (0.40) | HSD17B10PTGS1KDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1010693-B1 | Imidazoline derivatives, preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2003-09-24 | — | — | EP | disclosed |
| EP-1010693-A1 | Imidazoline derivatives, preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 2000-06-21 | — | — | EP | disclosed |