Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 4/20 | 0.34 |
| ▸ | HTR2C | P28335 | 4/20 | 0.34 |
| ▸ | HTR2B | P41595 | 4/20 | 0.34 |
| ▸ | PNMT | P11086 | 2/20 | 0.33 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.32 |
| ▸ | KIF11 | P52732 | 1/20 | 0.31 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.31 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.31 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6954716 | 0.83 | ADRA2A (0.46) | ADRA2A | |
| SCHEMBL6952820 | 0.80 | ADRA2A (0.30) | ADRA2A | |
| SCHEMBL6958705 | 0.77 | CYP11B2 (0.41) | HTR2AADRA2A | |
| SCHEMBL6954590 | 0.76 | HTR2A (0.42) | HTR2AHTR2CHTR2BADRA2A | |
| SCHEMBL6960771 | 0.76 | HTR2A (0.42) | HTR2AHTR2CHTR2BADRA2A | |
| SCHEMBL27500226 | 0.74 | HTR2A (0.36) | HTR2AHTR2CHTR2BDPP7PARP1 | |
| SCHEMBL6955673 | 0.71 | MCHR1 (0.34) | — | |
| SCHEMBL6951250 | 0.71 | PSEN1 (0.40) | PARP1PARP10 | |
| SCHEMBL11459008 | 0.68 | CFTR (0.39) | — | |
| SCHEMBL8092602 | 0.67 | TRPM2 (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1010693-B1 | Imidazoline derivatives, preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2003-09-24 | — | — | EP | disclosed |
| US-6127396-A | Imidazoline compounds | ADIR ET COMPAGNIE (FR) | 2000-10-03 | — | — | US | disclosed |