Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 2/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | BCL2 | P10415 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6952820 | 0.82 | ADRA2A (0.30) | ADRA2A | |
| SCHEMBL6954716 | 0.79 | ADRA2A (0.46) | ADRA2A | |
| SCHEMBL6958671 | 0.77 | HTR2A (0.34) | ADRA2AHTR2A | |
| SCHEMBL6954590 | 0.75 | HTR2A (0.42) | CYP11B2ADRA2AHTR2ADRD2DRD3 | |
| SCHEMBL6960771 | 0.75 | HTR2A (0.42) | CYP11B2ADRA2AHTR2ADRD2DRD3 | |
| SCHEMBL8533789 | 0.74 | CYP11B2 (0.45) | CYP11B2ALOX5BCL2DRD2DRD3 | |
| SCHEMBL6955673 | 0.73 | MCHR1 (0.34) | — | |
| SCHEMBL11282142 | 0.73 | CYP11B2 (0.44) | CYP11B2BCL2DRD2DRD3CYP11B1 | |
| SCHEMBL6949352 | 0.72 | AKR1C2 (0.47) | CYP11B2ALOX5 | |
| SCHEMBL7305935 | 0.71 | MTNR1A (0.43) | CYP11B2ALOX5CYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1010693-B1 | Imidazoline derivatives, preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2003-09-24 | — | — | EP | disclosed |
| US-6127396-A | Imidazoline compounds | ADIR ET COMPAGNIE (FR) | 2000-10-03 | — | — | US | disclosed |