Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.58 |
| ▸ | DRD3 | P35462 | 2/20 | 0.58 |
| ▸ | HTR1A | P08908 | 1/20 | 0.58 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.58 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.58 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.58 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.58 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.58 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6974927 | 0.90 | DRD2 (0.49) | DRD2DRD3HTR1AADRA2AADRA2C | |
| SCHEMBL6801822 | 0.85 | DRD2 (0.47) | DRD2DRD3HTR1AADRA2AADRA2C | |
| SCHEMBL6977453 | 0.85 | DRD2 (0.47) | DRD2DRD3HTR1AADRA2AADRA2C | |
| SCHEMBL7805256 | 0.82 | DRD2 (0.72) | DRD2DRD3HTR1AADRA2AADRA2C | |
| Fumaric Acid SCHEMBL6972673 | 0.82 | MAPT (0.45) | DRD2DRD3HTR1AADRA2AADRA2C | |
| Fumaric Acid SCHEMBL6972679 | 0.82 | MAPT (0.45) | DRD2DRD3HTR1AADRA2AADRA2C | |
| SCHEMBL6963642 | 0.81 | SIGMAR1 (0.86) | DRD2DRD3HTR1AADRA2AADRA2C | |
| SCHEMBL19852433 | 0.80 | GRIN2B (0.53) | DRD2HTR1ASIGMAR1KDM4ETSHR | |
| SCHEMBL6792729 | 0.79 | MTNR1A (0.50) | DRD2DRD3HTR1AADRA2AADRA2C | |
| SCHEMBL6794641 | 0.77 | SMN1; SMN2 (0.46) | DRD2DRD3HTR1AADRA2AADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0946538-B1 | INDANE OR DIHYDROINDOLE DERIVATIVES | LUNDBECK & CO AS H (DK) | 2003-08-06 | — | — | EP | claimed |
| US-6331544-B1 | TREATING POSITIVE AND NEGATIVE SYMPTOMS OF SCHIZOPHRENIA AND OTHER PSYCHOSES | H. LUNDBECK A/S (DK) | 2001-12-18 | — | — | US | claimed |
| US-20010051625-A1 | Indane or dihydroindole derivatives | H. LUNDBECK A/S (DK) | 2001-12-13 | — | — | US | claimed |
| EP-0946538-A1 | INDANE OR DIHYDROINDOLE DERIVATIVES | H. LUNDBECK A/S (DK) | 1999-10-06 | — | — | EP | claimed |
| WO-1998028290-A1 | INDANE OR DIHYDROINDOLE DERIVATIVES | H. LUNDBECK A/S (DK) | 1998-07-02 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010051625-A1 | Indane or dihydroindole derivatives | DRD2, SLC6A3, DRD1 | DRD2 1/4885DRD3 6/4885HTR1A 16/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.