Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.86 |
| ▸ | DRD2 | P14416 | 3/20 | 0.86 |
| ▸ | DRD3 | P35462 | 3/20 | 0.86 |
| ▸ | HTR1A | P08908 | 2/20 | 0.86 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.86 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.86 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.86 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.86 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.86 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29639702 | 0.92 | DRD2 (1.00) | SIGMAR1DRD2DRD3HTR1AADRA2A | |
| SCHEMBL7810984 | 0.92 | DRD2 (1.00) | SIGMAR1DRD2DRD3HTR1AADRA2A | |
| SCHEMBL7807312 | 0.84 | HTR1A (0.84) | SIGMAR1DRD2DRD3HTR1AADRA2A | |
| SCHEMBL7805322 | 0.83 | DRD2 (0.71) | SIGMAR1DRD2DRD3HTR1AADRA2A | |
| SCHEMBL7805320 | 0.83 | SIGMAR1 (0.71) | SIGMAR1DRD2DRD3HTR1AADRA2A | |
| SCHEMBL7810855 | 0.82 | SIGMAR1 (0.78) | SIGMAR1DRD2DRD3HTR1AADRA2A | |
| SCHEMBL7805016 | 0.82 | SIGMAR1 (0.78) | SIGMAR1DRD2DRD3HTR1AADRA2A | |
| SCHEMBL6960133 | 0.81 | DRD2 (0.58) | SIGMAR1DRD2DRD3HTR1AADRA2A | |
| SCHEMBL7805256 | 0.77 | DRD2 (0.72) | SIGMAR1DRD2DRD3HTR1AADRA2A | |
| SCHEMBL7814698 | 0.75 | DRD2 (0.60) | SIGMAR1DRD2DRD3HTR1AADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0946538-B1 | INDANE OR DIHYDROINDOLE DERIVATIVES | LUNDBECK & CO AS H (DK) | 2003-08-06 | — | — | EP | claimed |
| US-6331544-B1 | TREATING POSITIVE AND NEGATIVE SYMPTOMS OF SCHIZOPHRENIA AND OTHER PSYCHOSES | H. LUNDBECK A/S (DK) | 2001-12-18 | — | — | US | claimed |
| US-20010051625-A1 | Indane or dihydroindole derivatives | H. LUNDBECK A/S (DK) | 2001-12-13 | — | — | US | claimed |
| EP-0946538-A1 | INDANE OR DIHYDROINDOLE DERIVATIVES | H. LUNDBECK A/S (DK) | 1999-10-06 | — | — | EP | claimed |
| WO-1998028290-A1 | INDANE OR DIHYDROINDOLE DERIVATIVES | H. LUNDBECK A/S (DK) | 1998-07-02 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010051625-A1 | Indane or dihydroindole derivatives | DRD2, SLC6A3, DRD1 | SIGMAR1 121/4885DRD2 1/4885DRD3 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.