SCHEMBL6960221

SCHEMBL6960221

COC(=O)c1cc2c(O)cccc2n1S(=O)(=O)c1ccc(Cl)c(Cl)c1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CCR2 P41597 3/20 0.51
NOD1 Q9Y239 5/20 0.42
NOD2 Q9HC29 4/20 0.42
PTGDR2 Q9Y5Y4 2/20 0.41
MAPK1 P28482 1/20 0.40
LPAR1 Q92633 1/20 0.39
LPAR2 Q9HBW0 1/20 0.39
ALDH3A1 P30838 2/20 0.38
ALDH1A1 P00352 1/20 0.37
TSHR P16473 1/20 0.37
SUMO3 P55854 1/20 0.37
SUMO2 P61956 1/20 0.37
SUMO1 P63165 1/20 0.37
HTR6 P50406 1/20 0.36
F10 P00742 1/20 0.36
MEN1 O00255 1/20 0.36
NPC1 O15118 1/20 0.36
CYP1A2 P05177 1/20 0.36
CYP3A4 P08684 1/20 0.36
CYP2D6 P10635 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6953247 0.86 CCR2 (0.48) CCR2NOD1NOD2PTGDR2MAPK1
SCHEMBL6963990 0.83 CCR2 (0.74) CCR2NOD1NOD2ALDH3A1ALDH1A1
SCHEMBL10003163 0.80 NOD1 (0.53) NOD1NOD2PTGDR2ALDH1A1TSHR
SCHEMBL6595442 0.79 CCR2 (0.55) CCR2NOD1NOD2ALDH1A1TSHR
SCHEMBL6964954 0.77 CCR2 (0.56) CCR2NOD1NOD2
SCHEMBL7516484 0.76 MAPT (0.50) CCR2ALDH1A1TSHRMAPT
SCHEMBL10003206 0.74 NOD1 (0.58) NOD1NOD2PTGDR2ALDH1A1TSHR
SCHEMBL12228582 0.74 PTGDR2 (0.46) CCR2NOD1NOD2PTGDR2HTR6
SCHEMBL6302533 0.74 CCR2 (0.63) CCR2F10MAPTKMT2A
SCHEMBL30889617 0.73 NOD1 (0.51) NOD1NOD2PTGDR2ALDH1A1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1001935-B1 INDOLE DERIVATIVES AS MCP-1 RECEPTOR ANTAGONISTS ASTRAZENECA AB (SE) 2003-10-08 EP disclosed
US-6288103-B1 MONOCYTE CHEMOATTRACTANT PROTEINS ANTAGONIST SUCH AS N-(3-CHLOROPHENYLSULPHONYL)INDOLE-2-CARBOXYLIC ACID; ANTIINFLAMMATORY AGENTS ZENECA LIMITED (GB) 2001-09-11 US disclosed
EP-0691962-B1 1-AMINO-3-PHENOXY PROPANE DERIVATIVES AS MODULATORS OF MULTI-DRUG RESISTANCE BASF AG (DE) 2000-09-13 EP disclosed
EP-1001935-A1 INDOLE DERIVATIVES AS MCP-1 RECEPTOR ANTAGONISTS ZENECA LIMITED (GB) 2000-05-24 EP disclosed
WO-1999007678-A1 INDOLE DERIVATIVES AS MCP-1 RECEPTOR ANTAGONISTS ZENECA LIMITED (GB) 1999-02-18 WO disclosed
US-5622953-A DRUG RESISTANT TO ANTICANCER CHEMOTHERAPEUTIC DRUG BASF AKTIENGESELLSCHAFT (DE) 1997-04-22 US disclosed
EP-0691962-A1 1-AMINO-3-PHENOXY PROPANE DERIVATIVES AS MODULATORS OF MULTI-DRUG RESISTANCE BASF AKTIENGESELLSCHAFT (DE) 1996-01-17 EP disclosed
WO-1994022842-A1 1-AMINO-3-PHENOXY PROPANE DERIVATIVES AS MODULATORS OF MULTI-DRUG RESISTANCE BASF AKTIENGESELLSCHAFT (DE) 1994-10-13 WO disclosed