Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 1/20 | 0.36 |
| ▸ | ACE | P12821 | 2/20 | 0.35 |
| ▸ | F11 | P03951 | 1/20 | 0.33 |
| ▸ | F2RL1 | P55085 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | KEAP1 | Q14145 | 9/20 | 0.32 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.32 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4503987 | 0.82 | F11 (0.40) | ACEF11F2RL1ALDH1A1NPSR1 | |
| SCHEMBL6972820 | 0.80 | MEN1 (0.41) | ACEALDH1A1 | |
| SCHEMBL6967292 | 0.80 | KEAP1 (0.38) | F11F2RL1ALDH1A1NPSR1KEAP1 | |
| SCHEMBL3873900 | 0.79 | SIRT1 (0.40) | ACEF2RL1TSHR | |
| SCHEMBL6969807 | 0.79 | KEAP1 (0.42) | F11F2RL1ALDH1A1NPSR1KEAP1 | |
| SCHEMBL6967233 | 0.78 | ALDH1A1 (0.45) | ALDH1A1NPSR1KEAP1TSHRNFE2L2 | |
| SCHEMBL6974862 | 0.77 | ACE (0.40) | ACEF2RL1NPSR1TSHR | |
| SCHEMBL6965284 | 0.77 | NPC1 (0.46) | ACEALDH1A1TSHR | |
| SCHEMBL6960917 | 0.76 | L3MBTL1 (0.43) | F2RL1ALDH1A1L3MBTL1 | |
| SCHEMBL6961208 | 0.76 | SMN1; SMN2 (0.44) | ALDH1A1NPSR1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0832069-B1 | BIPHENYL-2-CARBOXYLIC ACID-TETRAHYDRO-ISOQUINOLIN-6-YL AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND/OR APOLIPOPROTEIN B (Apo B) SECRETION | PFIZER (US) | 2003-03-05 | — | — | EP | disclosed |
| EP-1181954-A2 | Biphenyl-2-carboxylic acid-tetrahydro-isoquinolin-6-yl amide derivatives, their preparation and use as inhibitors of microsomal triglyceride transfer protein and/or apolipoprotein B (ApoB) secretion | PFIZER INC. (US) | 2002-02-27 | — | — | EP | disclosed |