Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCAT2 | O15382 | 1/20 | 0.58 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | RORC | P51449 | 1/20 | 0.36 |
| ▸ | RORB | Q92753 | 1/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | IKBKB | O14920 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | HTR7 | P34969 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4717953 | 0.78 | BCAT2 (0.64) | BCAT2MAPK8MAPK10ALDH1A1KDM4E | |
| SCHEMBL12495840 | 0.77 | BCAT2 (0.62) | BCAT2MAPK8MAPK10ALDH1A1KDM4E | |
| SCHEMBL7472100 | 0.77 | BCAT2 (0.62) | BCAT2MAPK8MAPK10PKMRORC | |
| SCHEMBL27576830 | 0.74 | BCAT2 (0.58) | BCAT2MAPK8MAPK10ALDH1A1KDM4E | |
| SCHEMBL4445671 | 0.74 | BCAT2 (1.00) | BCAT2MAPK8MAPK10ALDH1A1RORB | |
| SCHEMBL28012573 | 0.73 | BCAT2 (0.57) | BCAT2MAPK8ALDH1A1KDM4EPOLB | |
| Hydrochloric Acid SCHEMBL31228833 | 0.73 | BCAT2 (0.96) | BCAT2MAPK8MAPK10ALDH1A1RORB | |
| SCHEMBL11817898 | 0.72 | ALDH1A1 (0.46) | ALDH1A1KDM4EPOLBPKMMEN1 | |
| SCHEMBL31661830 | 0.69 | MKNK1 (0.54) | BCAT2ALDH1A1KDM4EPOLBIRAK4 | |
| SCHEMBL10798532 | 0.69 | RORB (0.40) | BCAT2MAPK8MAPK10ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0713483-B1 | AMIDINE DERIVATIVES WITH NITRIC OXIDE SYNTHETASE ACTIVITIES | ASTRAZENECA AB (SE) | 2003-01-15 | — | — | EP | disclosed |
| US-6030985-A | Amidine derivatives with nitric oxide synthetase activities | ASTRA AKTIEBOLAG (SE) | 2000-02-29 | — | — | US | disclosed |
| US-5807885-A | Amidine derivatives with nitric oxide synthetase activities | ASTRA AKTIEBOLAG (SE) | 1998-09-15 | — | — | US | disclosed |
| WO-1995005363-A1 | AMIDINE DERIVATIVES WITH NITRIC OXIDE SYNTHETASE ACTIVITIES | ASTRA AKTIEBOLAG (SE) | 1995-02-23 | — | — | WO | disclosed |