Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 1/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.65 |
| ▸ | NPC1 | O15118 | 3/20 | 0.65 |
| ▸ | RAB9A | P51151 | 3/20 | 0.65 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.65 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.64 |
| ▸ | MEN1 | O00255 | 2/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.64 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.62 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.62 |
| ▸ | MITF | O75030 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | MMP13 | P45452 | 1/20 | 0.60 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.59 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.59 |
| ▸ | THRB | P10828 | 1/20 | 0.58 |
| ▸ | PTPRF | P10586 | 1/20 | 0.58 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.58 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.58 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11615300 | 0.94 | RAB9A (0.74) | CA2SMN1; SMN2NPC1RAB9ATAAR1 | |
| SCHEMBL16369739 | 0.89 | SMN1; SMN2 (0.71) | CA2SMN1; SMN2NPC1RAB9ATAAR1 | |
| SCHEMBL5767299 | 0.86 | CA2 (0.71) | CA2SMN1; SMN2NPC1RAB9ATAAR1 | |
| SCHEMBL14238254 | 0.86 | CA2 (0.71) | CA2SMN1; SMN2NPC1RAB9ATAAR1 | |
| SCHEMBL6962971 | 0.85 | SMN1; SMN2 (0.89) | SMN1; SMN2NPC1RAB9ATAAR1MEN1 | |
| SCHEMBL18610093 | 0.85 | CA2 (0.69) | CA2SMN1; SMN2NPC1RAB9AFFAR1 | |
| SCHEMBL6358626 | 0.85 | SMN1; SMN2 (0.75) | CA2SMN1; SMN2NPC1RAB9ATAAR1 | |
| SCHEMBL19358908 | 0.85 | CXCR4 (0.70) | CA2SMN1; SMN2NPC1RAB9ATAAR1 | |
| SCHEMBL4156900 | 0.84 | ALDH1A1 (0.67) | SMN1; SMN2NPC1RAB9ATAAR1FFAR1 | |
| SCHEMBL1083633 | 0.84 | MEN1 (0.77) | SMN1; SMN2RAB9AFFAR1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0713483-B1 | AMIDINE DERIVATIVES WITH NITRIC OXIDE SYNTHETASE ACTIVITIES | ASTRAZENECA AB (SE) | 2003-01-15 | — | — | EP | disclosed |
| CN-1071746-C | Amidine derivatives with nitric oxide synthetase activities | ASTERA CO (SE) | 2001-09-26 | — | — | CN | disclosed |
| US-6030985-A | Amidine derivatives with nitric oxide synthetase activities | ASTRA AKTIEBOLAG (SE) | 2000-02-29 | — | — | US | disclosed |
| US-5807885-A | Amidine derivatives with nitric oxide synthetase activities | ASTRA AKTIEBOLAG (SE) | 1998-09-15 | — | — | US | disclosed |
| CN-1132505-A | Amidine derivatives with nitric oxide synthetase activities | ASTERA CO (SE) | 1996-10-02 | — | — | CN | disclosed |
| EP-0713483-A1 | AMIDINE DERIVATIVES WITH NITRIC OXIDE SYNTHETASE ACTIVITIES | Astra Aktiebolag (SE) | 1996-05-29 | — | — | EP | disclosed |
| EP-0379416-B1 | Azabicycloheptene derivatives and their salts, process for their preparation, their use as medicaments and compositions containing them | ROUSSEL UCLAF (FR) | 1995-03-08 | — | — | EP | disclosed |
| WO-1995005363-A1 | AMIDINE DERIVATIVES WITH NITRIC OXIDE SYNTHETASE ACTIVITIES | ASTRA AKTIEBOLAG (SE) | 1995-02-23 | — | — | WO | disclosed |
| US-5086170-A | PROCESS FOR THE PREPARATION OF AZABICYCLO COMPOUNDS | ROUSSEL UCLAF (FR) | 1992-02-04 | — | — | US | disclosed |
| US-5059596-A | AZABICYCLO COMPOUNDS | ROUSSEL UCLAF (FR) | 1991-10-22 | — | — | US | disclosed |
| EP-0379416-A2 | Azabicycloheptene derivatives and their salts, process for their preparation, their use as medicaments and compositions containing them | ROUSSEL-UCLAF (FR) | 1990-07-25 | — | — | EP | disclosed |