Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.89 |
| ▸ | RAB9A | P51151 | 3/20 | 0.89 |
| ▸ | NPC1 | O15118 | 2/20 | 0.89 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.89 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.73 |
| ▸ | HPGD | P15428 | 2/20 | 0.73 |
| ▸ | MAPT | P10636 | 5/20 | 0.70 |
| ▸ | LMNA | P02545 | 2/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.70 |
| ▸ | USP2 | O75604 | 1/20 | 0.70 |
| ▸ | MAOA | P21397 | 2/20 | 0.66 |
| ▸ | KDM1A | O60341 | 1/20 | 0.66 |
| ▸ | MEN1 | O00255 | 3/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.61 |
| ▸ | ESRRG | P62508 | 1/20 | 0.61 |
| ▸ | PKM | P14618 | 1/20 | 0.60 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.60 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.60 |
| ▸ | MAOB | P27338 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11024162 | 0.94 | RAB9A (1.00) | SMN1; SMN2RAB9ANPC1TAAR1ALDH1A1 | |
| Nitric Acid SCHEMBL18329349 | 0.86 | RAB9A (0.76) | SMN1; SMN2RAB9ANPC1TAAR1ALDH1A1 | |
| SCHEMBL9110278 | 0.86 | RAB9A (0.67) | SMN1; SMN2RAB9ANPC1TAAR1ALDH1A1 | |
| SCHEMBL6961817 | 0.85 | CA2 (0.68) | SMN1; SMN2RAB9ANPC1TAAR1MEN1 | |
| SCHEMBL10160183 | 0.85 | SMN1; SMN2 (0.85) | SMN1; SMN2RAB9ANPC1TAAR1ALDH1A1 | |
| SCHEMBL4067332 | 0.84 | PKM (0.82) | SMN1; SMN2RAB9ANPC1TAAR1ALDH1A1 | |
| SCHEMBL6410116 | 0.84 | SMN1; SMN2 (0.72) | SMN1; SMN2RAB9ANPC1TAAR1ALDH1A1 | |
| SCHEMBL17372423 | 0.84 | RAB9A (0.81) | SMN1; SMN2RAB9ANPC1TAAR1ALDH1A1 | |
| SCHEMBL1695076 | 0.83 | SMN1; SMN2 (0.66) | SMN1; SMN2RAB9ANPC1TAAR1ALDH1A1 | |
| SCHEMBL751214 | 0.82 | HDAC2 (0.80) | SMN1; SMN2RAB9ANPC1TAAR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0713483-B1 | AMIDINE DERIVATIVES WITH NITRIC OXIDE SYNTHETASE ACTIVITIES | ASTRAZENECA AB (SE) | 2003-01-15 | — | — | EP | disclosed |
| US-6030985-A | Amidine derivatives with nitric oxide synthetase activities | ASTRA AKTIEBOLAG (SE) | 2000-02-29 | — | — | US | disclosed |
| US-5807885-A | Amidine derivatives with nitric oxide synthetase activities | ASTRA AKTIEBOLAG (SE) | 1998-09-15 | — | — | US | disclosed |
| WO-1995005363-A1 | AMIDINE DERIVATIVES WITH NITRIC OXIDE SYNTHETASE ACTIVITIES | ASTRA AKTIEBOLAG (SE) | 1995-02-23 | — | — | WO | disclosed |