Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | PEPD | P12955 | 1/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.30 |
| ▸ | CNR2 | P34972 | 1/20 | 0.30 |
| ▸ | RORC | P51449 | 1/20 | 0.30 |
| ▸ | FPR2 | P25090 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL696511 | 0.89 | KMT2A (0.33) | LMNA | |
| SCHEMBL697456 | 0.88 | PEPD (0.36) | ADORA2AADORA1PEPDMCHR1LMNA | |
| SCHEMBL694464 | 0.81 | MCHR1 (0.41) | ADORA2AADORA1MCHR1LMNACNR2 | |
| SCHEMBL696519 | 0.81 | FKBP1A (0.40) | RAB9ASMN1; SMN2SCN9A | |
| SCHEMBL695644 | 0.77 | KMT2A (0.35) | LMNASMN1; SMN2 | |
| SCHEMBL696054 | 0.71 | ACE (0.37) | LMNARAB9A | |
| SCHEMBL695637 | 0.69 | FKBP1A (0.42) | RAB9ASMN1; SMN2SCN9A | |
| SCHEMBL696423 | 0.68 | MCHR1 (0.42) | ADORA2AADORA1MCHR1CNR2FPR2 | |
| SCHEMBL696114 | 0.66 | DRD2 (0.38) | LMNAFPR2 | |
| SCHEMBL696150 | 0.65 | FKBP1A (0.40) | RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421826-A1 | PROLINE DERIVATIVES AS CATHEPSIN INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2012-02-29 | — | — | EP | disclosed |
| WO-2010121918-A1 | PROLINE DERIVATIVES AS CATHEPSIN INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2010-10-28 | — | — | WO | disclosed |