Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FKBP1A | P62942 | 11/20 | 0.39 |
| ▸ | FGF1 | P05230 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MMP1 | P03956 | 1/20 | 0.35 |
| ▸ | MMP7 | P09237 | 1/20 | 0.35 |
| ▸ | MMP8 | P22894 | 1/20 | 0.35 |
| ▸ | MMP12 | P39900 | 1/20 | 0.35 |
| ▸ | MMP13 | P45452 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6962479 | 1.00 | FKBP1A (0.39) | FKBP1AFGF1TP53MMP1MMP7 | |
| SCHEMBL6965713 | 0.81 | FKBP1A (0.37) | FKBP1AMMP1MMP7MMP8MMP12 | |
| SCHEMBL6965719 | 0.81 | FKBP1A (0.37) | FKBP1AMMP1MMP7MMP8MMP12 | |
| SCHEMBL6962473 | 0.81 | OPRK1 (0.45) | FKBP1ATP53 | |
| SCHEMBL6964692 | 0.81 | OPRK1 (0.45) | FKBP1ATP53 | |
| SCHEMBL6970227 | 0.73 | CCR4 (0.42) | FKBP1A | |
| SCHEMBL6967183 | 0.73 | JAK2 (0.32) | FKBP1AMMP1MMP7MMP13 | |
| SCHEMBL6958233 | 0.73 | JAK2 (0.32) | FKBP1AMMP1MMP7MMP13 | |
| SCHEMBL6962300 | 0.69 | MEN1 (0.34) | — | |
| SCHEMBL6969165 | 0.69 | JAK2 (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1060178-B1 | HETEROCYCLIC COMPOUNDS AS INHIBITORS OF ROTAMASE ENZYMES | PFIZER (US) | 2003-09-03 | — | — | EP | disclosed |
| EP-1060178-A1 | HETEROCYCLIC COMPOUNDS AS INHIBITORS OF ROTAMASE ENZYMES | PFIZER INC. (US) | 2000-12-20 | — | — | EP | disclosed |
| WO-1999045006-A1 | HETEROCYCLIC COMPOUNDS AS INHIBITORS OF ROTAMASE ENZYMES | PFIZER INC. (US) | 1999-09-10 | — | — | WO | disclosed |