Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FKBP1A | P62942 | 8/20 | 0.37 |
| ▸ | MMP1 | P03956 | 1/20 | 0.34 |
| ▸ | MMP7 | P09237 | 1/20 | 0.34 |
| ▸ | MMP8 | P22894 | 1/20 | 0.34 |
| ▸ | MMP12 | P39900 | 1/20 | 0.34 |
| ▸ | MMP13 | P45452 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | F2 | P00734 | 1/20 | 0.34 |
| ▸ | F10 | P00742 | 1/20 | 0.34 |
| ▸ | CCR1 | P32246 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6965719 | 1.00 | FKBP1A (0.37) | FKBP1AMMP1MMP7MMP8MMP12 | |
| SCHEMBL6962473 | 0.90 | OPRK1 (0.45) | FKBP1AMAPT | |
| SCHEMBL6964692 | 0.90 | OPRK1 (0.45) | FKBP1AMAPT | |
| SCHEMBL6962467 | 0.81 | FKBP1A (0.39) | FKBP1AMMP1MMP7MMP8MMP12 | |
| SCHEMBL6962479 | 0.81 | FKBP1A (0.39) | FKBP1AMMP1MMP7MMP8MMP12 | |
| SCHEMBL6967183 | 0.75 | JAK2 (0.32) | FKBP1AMMP1MMP7MMP13 | |
| SCHEMBL6958233 | 0.75 | JAK2 (0.32) | FKBP1AMMP1MMP7MMP13 | |
| SCHEMBL6970227 | 0.72 | CCR4 (0.42) | FKBP1AMEN1KMT2A | |
| SCHEMBL6968288 | 0.72 | OPRK1 (0.49) | FKBP1AKMT2A | |
| SCHEMBL6968285 | 0.72 | OPRK1 (0.49) | FKBP1AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1060178-B1 | HETEROCYCLIC COMPOUNDS AS INHIBITORS OF ROTAMASE ENZYMES | PFIZER (US) | 2003-09-03 | — | — | EP | disclosed |
| US-6610707-B1 | Moderate neuronal regeneration and outgrowth and can be used for treating neurological disorders arising from neurodegenerative diseases and nerve damage. | PFIZER INC. | 2003-08-26 | — | — | US | disclosed |