Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 2/20 | 0.32 |
| ▸ | JAK1 | P23458 | 2/20 | 0.32 |
| ▸ | JAK3 | P52333 | 2/20 | 0.32 |
| ▸ | TYK2 | P29597 | 1/20 | 0.32 |
| ▸ | SMYD3 | Q9H7B4 | 4/20 | 0.32 |
| ▸ | FKBP1A | P62942 | 6/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.31 |
| ▸ | MMP1 | P03956 | 1/20 | 0.31 |
| ▸ | MMP3 | P08254 | 1/20 | 0.31 |
| ▸ | MMP7 | P09237 | 1/20 | 0.31 |
| ▸ | MMP13 | P45452 | 1/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6967183 | 1.00 | JAK2 (0.32) | JAK2JAK1JAK3TYK2SMYD3 | |
| SCHEMBL6962300 | 0.83 | MEN1 (0.34) | JAK2JAK1JAK3TYK2SMYD3 | |
| SCHEMBL6969165 | 0.82 | JAK2 (0.30) | JAK2JAK1JAK3TYK2 | |
| SCHEMBL6959434 | 0.81 | SPHK1 (0.36) | JAK2JAK1JAK3TYK2FKBP1A | |
| SCHEMBL6959128 | 0.81 | SPHK1 (0.36) | JAK2JAK1JAK3TYK2FKBP1A | |
| SCHEMBL6964491 | 0.80 | KDM4E (0.35) | SMYD3ALDH1A1 | |
| SCHEMBL6968537 | 0.80 | ALOX5 (0.35) | FKBP1AALDH1A1HTTMMP1MMP7 | |
| SCHEMBL7234982 | 0.78 | L3MBTL1 (0.31) | SMYD3 | |
| SCHEMBL7234984 | 0.78 | L3MBTL1 (0.31) | SMYD3 | |
| SCHEMBL6963805 | 0.75 | ALDH1A1 (0.46) | FKBP1AALDH1A1HTTMMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1060178-B1 | HETEROCYCLIC COMPOUNDS AS INHIBITORS OF ROTAMASE ENZYMES | PFIZER (US) | 2003-09-03 | — | — | EP | disclosed |
| US-6610707-B1 | Moderate neuronal regeneration and outgrowth and can be used for treating neurological disorders arising from neurodegenerative diseases and nerve damage. | PFIZER INC. | 2003-08-26 | — | — | US | disclosed |