Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | MITF | O75030 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | ALDH5A1 | P51649 | 2/20 | 0.40 |
| ▸ | ABAT | P80404 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6967818 | 0.87 | ALDH1A1 (0.47) | POLBKDM4ERAB9APTGS2ALDH1A1 | |
| SCHEMBL3755148 | 0.80 | POLB (0.53) | POLBKDM4ERAB9AALDH1A1HTT | |
| SCHEMBL29914686 | 0.80 | POLB (0.53) | POLBKDM4ERAB9AALDH1A1HTT | |
| SCHEMBL10029204 | 0.79 | ALDH1A1 (0.67) | KDM4ERAB9AALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL7684154 | 0.78 | KDM4E (0.54) | POLBKDM4ERAB9APTGS2ALDH1A1 | |
| SCHEMBL21409465 | 0.78 | MITF (0.51) | POLBKDM4ERAB9AALDH1A1HTT | |
| SCHEMBL29957610 | 0.78 | KDM4E (0.54) | POLBKDM4ERAB9APTGS2ALDH1A1 | |
| SCHEMBL247350 | 0.78 | POLB (0.75) | POLBMEN1KMT2AHPGDMAPK1 | |
| SCHEMBL30612630 | 0.78 | POLB (0.75) | POLBMEN1KMT2AHPGDMAPK1 | |
| SCHEMBL16858580 | 0.77 | POLB (0.50) | POLBKDM4ERAB9AALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0906294-B1 | BENZOXAZINONE DOPAMINE D4 RECEPTOR ANTAGONISTS | WARNER LAMBERT CO (US) | 2003-01-29 | — | — | EP | disclosed |
| US-6177422-B1 | ANTIPSYCHOTIC AGENT WITH REDUCED SIDE EFFECTS | WARNER-LAMBERT COMPANY | 2001-01-23 | — | — | US | disclosed |
| EP-0906294-A1 | BENZOXAZINONE DOPAMINE D4 RECEPTOR ANTAGONISTS | WARNER-LAMBERT COMPANY (US) | 1999-04-07 | — | — | EP | disclosed |
| WO-1997045419-A1 | BENZOXAZINONE DOPAMINE D4 RECEPTOR ANTAGONISTS | WARNER-LAMBERT COMPANY (US) | 1997-12-04 | — | — | WO | disclosed |