Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 11/20 | 0.44 |
| ▸ | HTR1A | P08908 | 4/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.41 |
| ▸ | DRD3 | P35462 | 4/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.41 |
| ▸ | HTR2A | P28223 | 3/20 | 0.41 |
| ▸ | HRH1 | P35367 | 3/20 | 0.41 |
| ▸ | HTR2B | P41595 | 3/20 | 0.41 |
| ▸ | DRD1 | P21728 | 3/20 | 0.41 |
| ▸ | DRD5 | P21918 | 2/20 | 0.41 |
| ▸ | HTR7 | P34969 | 2/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8164638 | 0.90 | DRD2 (0.51) | DRD2HTR1ASLC6A4DRD3SLC6A3 | |
| SCHEMBL8163784 | 0.81 | DRD2 (0.46) | DRD2HTR1ASLC6A4DRD3SLC6A3 | |
| SCHEMBL7665768 | 0.79 | DRD2 (0.66) | DRD2HTR1ASLC6A4DRD3SLC6A3 | |
| Hydrochloric Acid SCHEMBL7658312 | 0.78 | DRD2 (0.64) | DRD2HTR1ASLC6A4DRD3SLC6A3 | |
| SCHEMBL6963309 | 0.76 | CACNA1G (0.41) | DRD2HTR1AHTR2AHTR2BOPRM1 | |
| SCHEMBL6968366 | 0.76 | ADRA1A (0.54) | DRD2HTR7ADRA1AOPRM1KCNH2 | |
| SCHEMBL7662402 | 0.75 | DRD2 (0.46) | DRD2HRH1ADRA2AADRA1AOPRM1 | |
| Hydrochloric Acid SCHEMBL7664056 | 0.74 | DRD2 (0.45) | DRD2HRH1ADRA2AADRA1AOPRM1 | |
| SCHEMBL6968347 | 0.71 | MMP9 (0.44) | ADRA2AADRA1AADRA2BADRA2CMEN1 | |
| SCHEMBL8156898 | 0.71 | ADRA1A (0.47) | DRD2HTR7ADRA1AOPRM1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0988295-A4 | HETEROCYCLIC SUBSTITUTED PIPERIDINES AND USES THEREOF | SYNAPTIC PHARMA CORP (US) | 2003-08-13 | — | — | EP | disclosed |
| US-6159990-A | Oxazolidinones as α1A receptor antagonists | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 2000-12-12 | — | — | US | disclosed |
| EP-0988295-A1 | HETEROCYCLIC SUBSTITUTED PIPERIDINES AND USES THEREOF | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 2000-03-29 | — | — | EP | disclosed |
| WO-1998057940-A1 | HETEROCYCLIC SUBSTITUTED PIPERIDINES AND USES THEREOF | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 1998-12-23 | — | — | WO | disclosed |