Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.51 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.51 |
| ▸ | LTA4H | P09960 | 1/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.49 |
| ▸ | FAAH | O00519 | 1/20 | 0.48 |
| ▸ | HTR1A | P08908 | 2/20 | 0.46 |
| ▸ | HTR7 | P34969 | 1/20 | 0.44 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.44 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.44 |
| ▸ | UBE2M | P61081 | 1/20 | 0.44 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.44 |
| ▸ | MET | P08581 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6968869 | 0.81 | DRD2 (0.47) | DRD2SLC6A3SLC6A4LTA4HSIGMAR1 | |
| SCHEMBL13490057 | 0.75 | SLC6A3 (0.60) | DRD2SLC6A3SLC6A4LTA4HSIGMAR1 | |
| SCHEMBL18917601 | 0.75 | SLC6A3 (0.77) | DRD2SLC6A3SLC6A4LTA4HSIGMAR1 | |
| SCHEMBL5302082 | 0.73 | LTA4H (0.86) | SLC6A3LTA4HSIGMAR1HRH3GRIN2B | |
| SCHEMBL28143698 | 0.73 | LOXL2 (0.53) | — | |
| SCHEMBL83687 | 0.72 | SIGMAR1 (0.86) | SLC6A3LTA4HSIGMAR1HRH3GRIN2B | |
| Hydrochloric Acid SCHEMBL11155632 | 0.72 | SLC6A3 (0.63) | DRD2SLC6A3SLC6A4LTA4HSIGMAR1 | |
| SCHEMBL6963851 | 0.71 | SLC6A3 (0.51) | DRD2SLC6A3SLC6A4LTA4HSIGMAR1 | |
| Hydrochloric Acid SCHEMBL7239522 | 0.70 | LTA4H (0.80) | SLC6A3LTA4HSIGMAR1HRH3GRIN2B | |
| SCHEMBL20382580 | 0.70 | LTA4H (0.86) | SLC6A3LTA4HSIGMAR1HRH3GRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1995005363-A1 | AMIDINE DERIVATIVES WITH NITRIC OXIDE SYNTHETASE ACTIVITIES | ASTRA AKTIEBOLAG (SE) | 1995-02-23 | — | — | WO | claimed |
| EP-0713483-B1 | AMIDINE DERIVATIVES WITH NITRIC OXIDE SYNTHETASE ACTIVITIES | ASTRAZENECA AB (SE) | 2003-01-15 | — | — | EP | disclosed |
| US-6030985-A | Amidine derivatives with nitric oxide synthetase activities | ASTRA AKTIEBOLAG (SE) | 2000-02-29 | — | — | US | disclosed |
| US-5807885-A | Amidine derivatives with nitric oxide synthetase activities | ASTRA AKTIEBOLAG (SE) | 1998-09-15 | — | — | US | disclosed |
| WO-1995005363-A1 | AMIDINE DERIVATIVES WITH NITRIC OXIDE SYNTHETASE ACTIVITIES | ASTRA AKTIEBOLAG (SE) | 1995-02-23 | — | — | WO | disclosed |